{"id":"W2883245844","doi":"10.1016/j.oraloncology.2018.07.010","title":"ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition","year":2018,"lang":"en","type":"article","venue":"Oral Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"HRAS; MAPK/ERK pathway; Mutant; PI3K/AKT/mTOR pathway; Cancer research; Signalling; Chemistry; Cell biology; Biology; Mutation; Signal transduction; KRAS; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301067,0.0002500327,0.0002868607,0.000254322,0.000255732,0.0004659125,0.000214891,0.0002800774,0.002364414],"category_scores_gemma":[0.00011394,0.0001391874,0.0002756718,0.0002725249,0.0002684695,0.0001712798,0.0001659418,0.000712112,0.0005344901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005333224,"about_ca_system_score_gemma":0.0004688435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004744013,"about_ca_topic_score_gemma":0.00613612,"domain_scores_codex":[0.9998195,0.00001843992,0.00001810548,0.00002172179,0.00005540262,0.00006681704],"domain_scores_gemma":[0.999936,0.00001284588,0.000009244044,0.00001375819,0.000007656116,0.00002048107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003241468,0.0001283199,0.000489119,0.00003712775,0.00001334603,0.0001429156,0.00003364887,0.0002344859,0.9958176,0.0003038545,0.0004969758,0.001978453],"study_design_scores_gemma":[0.00007326875,0.0005586104,0.0122402,0.000006921789,0.00003172088,0.0005574123,0.0001651403,0.00299119,0.9773813,0.0001087268,0.005875055,0.00001045518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956319,0.0004160826,0.0003993834,0.0001607527,0.00004073901,0.00002500793,0.0007386091,0.0000959724,0.002491666],"genre_scores_gemma":[0.9966918,0.0001936982,0.0003210758,0.0000389091,0.000005765875,0.00002012369,0.0005449487,0.00001065677,0.002172931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004744013,"threshold_uncertainty_score":0.009432793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02045338338365146,"score_gpt":0.3082528344906109,"score_spread":0.2877994511069595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}