{"id":"W2883250051","doi":"10.1002/hep.30147","title":"A Coiled‐Coil Domain Containing 50 Splice Variant Is Modulated by Serine/Arginine‐Rich Splicing Factor 3 and Promotes Hepatocellular Carcinoma in Mice by the Ras Signaling Pathway","year":2018,"lang":"en","type":"article","venue":"Hepatology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Connaught Fund","keywords":"Splicing factor; Cancer research; Biology; RNA splicing; HBx; SR protein; Kinase; Signal transduction; Alternative splicing; Ectopic expression; MAPK/ERK pathway; Protein kinase A; Cell biology; Messenger RNA; Transfection; Gene; RNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005444208,0.0003319202,0.0004230358,0.00008138642,0.0002601365,0.00004809525,0.0003389591,0.0003255912,0.00005233718],"category_scores_gemma":[0.0001360828,0.0002696322,0.00006439675,0.0002229769,0.0002811492,0.00001278855,0.0002618684,0.0003094198,0.00001187353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004192843,"about_ca_system_score_gemma":0.0001392165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002133776,"about_ca_topic_score_gemma":0.0003395709,"domain_scores_codex":[0.997452,0.0003391849,0.0004575706,0.0007517737,0.0001957423,0.0008037367],"domain_scores_gemma":[0.9990282,0.0001091941,0.000155445,0.0003939284,0.0001332088,0.0001800238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002153889,0.00004613775,0.1172323,0.00003272131,0.00006019756,0.00005998378,0.0006918156,0.000001078907,0.8804073,0.000029425,0.000815364,0.0004082239],"study_design_scores_gemma":[0.001773442,0.0009132196,0.00112187,0.00004374545,0.00001682585,0.0003294072,0.0006434486,0.01853504,0.9691961,0.000086664,0.006887168,0.0004530812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950271,0.002429077,0.001061642,0.0006890743,0.00006954939,0.0004846469,0.00007677144,0.00002343401,0.0001386812],"genre_scores_gemma":[0.9981237,0.0001082934,0.0002869998,0.0008388068,0.0001225647,0.00006206924,0.0001032021,0.00005046936,0.0003038894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1161104,"threshold_uncertainty_score":0.9999756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186155001670084,"score_gpt":0.2392541661232619,"score_spread":0.2273926161065611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}