{"id":"W2883250051","doi":"10.1002/hep.30147","title":"A Coiled‐Coil Domain Containing 50 Splice Variant Is Modulated by Serine/Arginine‐Rich Splicing Factor 3 and Promotes Hepatocellular Carcinoma in Mice by the Ras Signaling Pathway","year":2018,"lang":"en","type":"article","venue":"Hepatology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Connaught Fund","keywords":"Splicing factor; Cancer research; Biology; RNA splicing; HBx; SR protein; Kinase; Signal transduction; Alternative splicing; Ectopic expression; MAPK/ERK pathway; Protein kinase A; Cell biology; Messenger RNA; Transfection; Gene; RNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000236458,0.0004707743,0.0002832499,0.0006943916,0.0002224709,0.0002085828,0.000156452,0.0003080161,0.001808708],"category_scores_gemma":[0.0001335111,0.0002846452,0.0005154646,0.0002416518,0.0003430684,0.0001157935,0.0002066375,0.0005385125,0.000540035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003742681,"about_ca_system_score_gemma":0.000195585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007974427,"about_ca_topic_score_gemma":0.00118434,"domain_scores_codex":[0.9997638,0.00004468376,0.00002320483,0.0000480858,0.00005043425,0.00006979575],"domain_scores_gemma":[0.9997599,0.00002064865,0.00009880753,0.00002092714,0.00001008407,0.00008966652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002442604,0.00003418481,0.0005868915,0.00001661465,0.00000886233,0.0001924885,0.0000131225,0.00004008465,0.9980208,0.0001113508,0.00008988667,0.0006414771],"study_design_scores_gemma":[0.0001290364,0.001004679,0.04898333,0.00001692242,0.00007839907,0.002366703,0.00008911109,0.004324091,0.9382676,0.0003231622,0.004390684,0.00002613368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962941,0.0006145111,0.001431349,0.000165502,0.00003416292,0.0000195239,0.0003491953,0.0001812503,0.0009103737],"genre_scores_gemma":[0.995994,0.0003978788,0.0007071722,0.00007767467,0.00001431978,0.00003409412,0.0005677283,0.00003873648,0.002168299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808708,"threshold_uncertainty_score":0.006050706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186155001670084,"score_gpt":0.2392541661232619,"score_spread":0.2273926161065611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}