{"id":"W2883254266","doi":"10.1128/aac.00512-18","title":"Comprehensive Substrate Characterization of 22 Antituberculosis Drugs for Multiple Solute Carrier (SLC) Uptake Transporters<i>In Vitro</i>","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Korea Health Industry Development Institute; World Health Organization","keywords":"In vitro; Transporter; Substrate specificity; Pharmacology; Chemistry; Solute carrier family; Membrane transport protein; Substrate (aquarium); Biochemistry; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003293809,0.000435178,0.0006489853,0.0002528375,0.0002322099,0.0004635131,0.0001777575,0.0002959856,0.0008684802],"category_scores_gemma":[0.0005895073,0.0001079396,0.0003696196,0.000385024,0.0001313368,0.0003134434,0.0001307974,0.0002391586,0.0004111106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003423427,"about_ca_system_score_gemma":0.0005144186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002135105,"about_ca_topic_score_gemma":0.002761244,"domain_scores_codex":[0.9997485,0.00005676849,0.00003294454,0.0000511814,0.00007154766,0.00003912775],"domain_scores_gemma":[0.9997831,0.00005018295,0.00004683243,0.00002409867,0.00007530804,0.0000205198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002031722,0.00002775808,0.002550831,0.00007901661,0.00002607652,0.0001047262,0.00003101082,0.000258195,0.9887313,0.00006744689,0.00009653364,0.007823939],"study_design_scores_gemma":[0.000007426823,0.0004455391,0.008573637,0.000007424238,0.00005771506,0.000706573,0.00004776717,0.001865906,0.9850545,0.00004689382,0.003171042,0.00001560569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835893,0.005216417,0.00771303,0.0001018502,0.00002241478,0.00005652804,0.00125018,0.0001143275,0.001936066],"genre_scores_gemma":[0.985415,0.002293086,0.008154773,0.00007179403,0.000007405893,0.00003176197,0.002589496,0.00004416556,0.001392559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002135105,"threshold_uncertainty_score":0.004245341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406180755873053,"score_gpt":0.2458633543762636,"score_spread":0.2318015468175331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}