{"id":"W2883260430","doi":"10.1007/s12028-018-0575-z","title":"Clinical Trial Protocol: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage [NEWTON-2 (Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After SubarachNoid Hemorrhage)]","year":2018,"lang":"en","type":"article","venue":"Neurocritical Care","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Nimodipine; Tolerability; Anesthesia; Clinical endpoint; Subarachnoid hemorrhage; Placebo; Randomized controlled trial; Multicenter trial; Regimen; Clinical trial; Adverse effect; Neurointensive care; Dosing; Surgery; Internal medicine; Multicenter study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007286914,0.0007232305,0.002641616,0.0003234558,0.0002710183,0.0001220028,0.000335444,0.0002007525,0.00007909623],"category_scores_gemma":[0.0007357342,0.0005778492,0.0003311428,0.0005891721,0.0005004458,0.0002247098,0.0002816898,0.0007277596,0.00002347106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002391631,"about_ca_system_score_gemma":0.0002220845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002191952,"about_ca_topic_score_gemma":0.001357813,"domain_scores_codex":[0.9940046,0.0006846497,0.002091965,0.001550474,0.0007583017,0.0009099749],"domain_scores_gemma":[0.9966187,0.0005529525,0.0002352648,0.0009276521,0.0009397584,0.000725712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9779139,0.005608553,0.004378719,0.001118838,0.00004842745,0.0007787009,0.002506579,0.00005306908,0.001878474,0.00001857913,0.000006822184,0.005689402],"study_design_scores_gemma":[0.9441102,0.04234495,0.001860512,0.0002377386,0.0009063347,0.0001167302,0.001630533,0.001819753,0.006384819,0.000003203575,0.00002275524,0.0005625438],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8914877,0.0000878847,0.0007819945,0.000889709,0.000188425,0.1061509,0.0001153266,0.0001289804,0.0001691156],"genre_scores_gemma":[0.958296,0.000001186572,0.005628783,0.00049334,0.0004906103,0.03489373,0.00007221475,0.00008884461,0.0000352914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07125717,"threshold_uncertainty_score":0.9996673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02655586471223254,"score_gpt":0.3537777520877344,"score_spread":0.3272218873755019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}