{"id":"W2883314555","doi":"10.1128/jvi.01080-18","title":"SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Gp41; Trimer; Glycoprotein; Biology; Conformational change; Protein structure; Viral envelope; Viral entry; Transmembrane protein; Biophysics; Cell biology; Biochemistry; Virus; Receptor; Virology; Chemistry; Viral replication; Epitope; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006025426,0.0001137422,0.00007513843,0.00005459136,0.0001175903,0.0001853556,0.0001305637,0.0002208067,0.002769118],"category_scores_gemma":[0.00013109,0.00006681737,0.00009896626,0.00004987632,0.0001482009,0.0001441171,0.0001123026,0.0003504023,0.0002103653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001860272,"about_ca_system_score_gemma":0.0001194414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004832095,"about_ca_topic_score_gemma":0.0006757778,"domain_scores_codex":[0.9999352,0.000009125264,0.000004046964,0.000009003192,0.000009839916,0.00003276546],"domain_scores_gemma":[0.9999487,0.00001307513,0.000009716353,0.000004657442,0.000005247486,0.0000184581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006193438,0.0001150525,0.0007253386,0.00001788103,0.000005964731,0.00008034069,0.00001688033,0.0001294737,0.9964752,0.0001139241,0.00006022476,0.001640445],"study_design_scores_gemma":[0.00005833801,0.001081595,0.01745304,0.000005418844,0.00001867504,0.0002565795,0.00009094388,0.0009096999,0.9789179,0.0001195465,0.001082392,0.00000586723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991283,0.0001136504,0.0000844739,0.00001969483,0.000006912212,0.000005015188,0.00004623286,0.000004310706,0.0005915366],"genre_scores_gemma":[0.9991308,0.00009666614,0.00009742876,0.00002576524,0.00000246735,0.000004381513,0.00007938204,0.000002986533,0.0005602044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002769118,"threshold_uncertainty_score":0.009263575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03139771025151937,"score_gpt":0.3113949679268146,"score_spread":0.2799972576752952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}