{"id":"W2883390145","doi":"10.1016/j.ymthe.2018.07.009","title":"MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto; York Central Hospital; Canadian Blood Services; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; York University","funders":"Canadian Institutes of Health Research; Peking University; Chinese Academy of Sciences; York University","keywords":"Spiral artery; Trophoblast; Gene silencing; microRNA; Decidua; Placenta; Biology; Preeclampsia; Transforming growth factor; Downregulation and upregulation; Cell biology; Cellular differentiation; Placentation; Cancer research; Immunology; Andrology; Medicine; Fetus; Gene; Pregnancy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005263581,0.0002791167,0.0003381375,0.0002801228,0.0003276533,0.0006460669,0.0002245364,0.0005570555,0.001985202],"category_scores_gemma":[0.0008656403,0.0002379711,0.0004552677,0.0001709075,0.0004299314,0.0002452736,0.0003073648,0.0008422651,0.000314936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000293728,"about_ca_system_score_gemma":0.0004649121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002951684,"about_ca_topic_score_gemma":0.0003193926,"domain_scores_codex":[0.9996064,0.0001489042,0.00003659853,0.00006732012,0.00007832587,0.00006245671],"domain_scores_gemma":[0.9998029,0.0000668853,0.0000561335,0.00002282465,0.00002131734,0.00002993981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009554656,0.001267652,0.01663694,0.0008674581,0.0003402134,0.001853879,0.0004180552,0.0003821525,0.8944077,0.002862026,0.00151474,0.0698944],"study_design_scores_gemma":[0.001233211,0.01107232,0.07247994,0.0001489304,0.001401355,0.005276245,0.0007812838,0.003483632,0.8625025,0.001985749,0.03957979,0.00005506969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818093,0.006524015,0.003579213,0.0006777985,0.0003005857,0.00008112715,0.0001573496,0.00008276355,0.006787896],"genre_scores_gemma":[0.9932186,0.002295921,0.001540613,0.0003425344,0.00005821627,0.0001144313,0.0001539704,0.00001798911,0.002257744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001985202,"threshold_uncertainty_score":0.00664115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01775431336508303,"score_gpt":0.2473407890044006,"score_spread":0.2295864756393175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}