{"id":"W2883431999","doi":"10.1038/s41591-018-0125-4","title":"Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo","year":2018,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":307,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Nature","keywords":"Gluconeogenesis; Metformin; Pyruvate carboxylase; Endocrinology; Internal medicine; Cytosol; Mitochondrion; Biguanide; Citrate synthase; Chemistry; Biology; Biochemistry; Metabolism; Enzyme; Diabetes mellitus; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005055316,0.0002155314,0.0003057956,0.000123445,0.00004927673,0.000005768699,0.0002316309,0.0005170885,0.0005356778],"category_scores_gemma":[0.0001854494,0.0001672439,0.00005581181,0.0002189701,0.0001302326,0.000004473108,0.00008423105,0.0002667005,0.0000186513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002648681,"about_ca_system_score_gemma":0.00006388268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000617625,"about_ca_topic_score_gemma":0.0004173836,"domain_scores_codex":[0.9985467,0.00005862667,0.0002821125,0.0004475623,0.0003195214,0.00034552],"domain_scores_gemma":[0.9992105,0.00001179779,0.0000917294,0.0004085096,0.0001514397,0.0001260386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001061592,0.00003734539,0.00008335008,0.00002295385,0.00004129935,0.00001199009,0.0001296983,3.82847e-7,0.9370972,0.0004296564,0.005341287,0.05669868],"study_design_scores_gemma":[0.001092245,0.0002860696,0.00006712007,0.00003921715,0.00003150065,0.00002067256,0.00005248532,0.00001318625,0.7413516,0.000681672,0.256214,0.0001502984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7568601,0.2376485,0.0005899214,0.0002124409,0.001337873,0.0002533483,0.00001627306,0.00001949142,0.003062071],"genre_scores_gemma":[0.9793044,0.01273349,0.0003559456,0.003536562,0.002849879,0.00003627776,0.00004340083,0.00003375097,0.001106256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2508727,"threshold_uncertainty_score":0.6820008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004965925082070805,"score_gpt":0.2571825532788292,"score_spread":0.2522166281967583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}