{"id":"W2883526689","doi":"10.1111/acel.12812","title":"Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells","year":2018,"lang":"en","type":"article","venue":"Aging Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Consejo Nacional de Investigaciones Científicas y Técnicas; International Union of Biochemistry and Molecular Biology","keywords":"Oxidative stress; Mitochondrion; Reactive oxygen species; Biology; Cell biology; Oxidative phosphorylation; Catalase; Antioxidant; Phenotype; Homeostasis; Mitochondrial ROS; Senescence; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304043,0.0001481577,0.0002363154,0.000151823,0.00006807412,0.00002319506,0.000109837,0.00007743096,0.0005815233],"category_scores_gemma":[0.0001294326,0.0001400475,0.00004043612,0.0003330324,0.0001844163,0.0001591839,0.00005303276,0.000185789,0.0002858023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008184605,"about_ca_system_score_gemma":0.00007500968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001276938,"about_ca_topic_score_gemma":0.00004697658,"domain_scores_codex":[0.9987041,0.00008790144,0.0002612075,0.0003478605,0.0002511929,0.0003477354],"domain_scores_gemma":[0.999257,0.0001337014,0.00004340098,0.0003193578,0.0001016487,0.0001448404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002075333,0.00190226,0.2168211,0.001159286,0.00004180533,0.001164262,0.01219127,0.00001347913,0.7573308,0.000455102,0.004713302,0.003999868],"study_design_scores_gemma":[0.002871095,0.0009394367,0.2976623,0.0009118724,0.0001125377,0.00009311101,0.001439845,0.001724322,0.6867071,0.0006124261,0.006299565,0.0006263772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932371,0.0000980625,0.0006890904,0.0003294662,0.0002928214,0.0002785934,0.000007382348,0.00006948102,0.00499803],"genre_scores_gemma":[0.9963742,0.00003126476,0.001306843,0.000424132,0.0001016636,0.000007301071,0.00002240844,0.00002427449,0.001707937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08084118,"threshold_uncertainty_score":0.6367273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420617542151734,"score_gpt":0.2920553713121837,"score_spread":0.2778491958906664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}