{"id":"W2883526689","doi":"10.1111/acel.12812","title":"Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells","year":2018,"lang":"en","type":"article","venue":"Aging Cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Consejo Nacional de Investigaciones Científicas y Técnicas; International Union of Biochemistry and Molecular Biology","keywords":"Oxidative stress; Mitochondrion; Reactive oxygen species; Biology; Cell biology; Oxidative phosphorylation; Catalase; Antioxidant; Phenotype; Homeostasis; Mitochondrial ROS; Senescence; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008134,0.0003543134,0.0005490847,0.0002616484,0.0001508915,0.0002883691,0.000240005,0.0002857287,0.002271835],"category_scores_gemma":[0.0001872553,0.0001296003,0.0002249101,0.0001573855,0.0001703577,0.000240765,0.0002446068,0.0005095716,0.0003909606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396214,"about_ca_system_score_gemma":0.0002266264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005197593,"about_ca_topic_score_gemma":0.000689953,"domain_scores_codex":[0.9998837,0.00002332317,0.00002136891,0.00002541135,0.00001998712,0.00002627872],"domain_scores_gemma":[0.999848,0.00002839393,0.00003335868,0.00002849218,0.00002067774,0.00004110715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000335878,0.00007379618,0.0001690585,0.00005802535,0.00000965961,0.00007247367,0.000018798,0.00004247465,0.9962996,0.00009939979,0.0001139317,0.002707021],"study_design_scores_gemma":[0.0000594656,0.0008573825,0.002755782,0.00001184793,0.00002858442,0.0003137907,0.00004372242,0.0004942307,0.9907142,0.00007206086,0.004643627,0.000005157445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930699,0.00238967,0.002316692,0.0001701899,0.00007946074,0.00003300619,0.0005462228,0.0001777552,0.001217074],"genre_scores_gemma":[0.9940691,0.001131521,0.001310338,0.00007817239,0.00001362428,0.00003736226,0.0007500575,0.00002788051,0.002581892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002271835,"threshold_uncertainty_score":0.007600009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420617542151734,"score_gpt":0.2920553713121837,"score_spread":0.2778491958906664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}