{"id":"W2883540904","doi":"10.1016/j.jcf.2018.07.001","title":"R560S: A class II CFTR mutation that is not rescued by current modulators","year":2018,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Department of Bioproducts and Biosystems Engineering, University of Minnesota; Choquette Family Foundation; Media Development Authority - Singapore","keywords":"Mutation; Cystic fibrosis; Medicine; Western blot; Messenger RNA; Cell biology; Cystic fibrosis transmembrane conductance regulator; Molecular biology; Biology; Cancer research; Gene; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002206463,0.001081726,0.001048108,0.0004919441,0.0006942565,0.0005490033,0.0009798622,0.004109683,0.006570584],"category_scores_gemma":[0.001232247,0.0001992923,0.001155792,0.0004282505,0.001021236,0.0005050788,0.0005153686,0.001404656,0.003250437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004382381,"about_ca_system_score_gemma":0.0006996902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003067068,"about_ca_topic_score_gemma":0.001972055,"domain_scores_codex":[0.9996069,0.00003858851,0.00007843332,0.00009315679,0.00009997212,0.00008304483],"domain_scores_gemma":[0.9994393,0.0001581765,0.0001150813,0.00004427369,0.00005574495,0.0001874095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001951492,0.000322385,0.004757603,0.0002686376,0.0001507899,0.3534127,0.0003014246,0.0008031025,0.5965332,0.003026755,0.01229176,0.02618024],"study_design_scores_gemma":[0.0008399913,0.001974137,0.02353565,0.0001918797,0.0004446025,0.5452301,0.0005345425,0.004743165,0.3570438,0.002736963,0.06249639,0.0002288888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438787,0.003136317,0.005275322,0.008834721,0.003682113,0.0002230042,0.006206484,0.001143252,0.02762007],"genre_scores_gemma":[0.9878066,0.0006865098,0.002116401,0.001124755,0.0001794237,0.00003994472,0.001443279,0.0001956269,0.006407447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006570584,"threshold_uncertainty_score":0.02198076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02390906090795319,"score_gpt":0.3307678880048296,"score_spread":0.3068588270968765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}