{"id":"W2883557754","doi":"10.1038/s41413-018-0022-y","title":"Ciliary parathyroid hormone signaling activates transforming growth factor-β to maintain intervertebral disc homeostasis during aging","year":2018,"lang":"en","type":"article","venue":"Bone Research","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Johns Hopkins University; National Institute of Diabetes and Digestive and Kidney Diseases; Foundation for the National Institutes of Health","keywords":"Parathyroid hormone; Homeostasis; Transforming growth factor; Endocrinology; Hormone; Internal medicine; Growth hormone; Iron homeostasis; Medicine; Metabolism; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009734283,0.0002974221,0.00054875,0.0008943686,0.0004135223,0.00009105944,0.0003005378,0.0001628905,0.0006225173],"category_scores_gemma":[0.0005460746,0.0002512673,0.0002428867,0.000923806,0.0003025234,0.0003895829,0.0002952533,0.0008198587,0.0005429843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003179113,"about_ca_system_score_gemma":0.0001304674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003836024,"about_ca_topic_score_gemma":0.00005965848,"domain_scores_codex":[0.9964766,0.0002443175,0.0005197989,0.0006811202,0.0007785868,0.001299585],"domain_scores_gemma":[0.9984972,0.00005652919,0.00004741395,0.0004510741,0.0004328229,0.0005149373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003737893,0.0001962179,0.001827559,0.0001459629,0.0001011479,0.0004842283,0.001966087,4.085039e-7,0.9859081,0.0003527182,0.002306977,0.006336842],"study_design_scores_gemma":[0.001923804,0.002735836,0.1568147,0.0004671316,0.00002951623,0.0002676818,0.002828347,0.0001265445,0.8337478,0.0003761785,0.0003145932,0.0003678678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990716,0.0009790045,0.001536205,0.003936396,0.00006857528,0.0007001373,0.00002905834,0.0001307196,0.001903842],"genre_scores_gemma":[0.9969605,0.00011182,0.0008652573,0.0002825298,0.000574854,0.00008921686,0.00002495814,0.00007111306,0.001019818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1549871,"threshold_uncertainty_score":0.999994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06842040909869491,"score_gpt":0.3836258914583179,"score_spread":0.315205482359623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}