{"id":"W2883558292","doi":"10.1016/j.bmc.2018.07.026","title":"Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen – A new hybrid design paradigm","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Histone deacetylase; Tamoxifen; Estrogen receptor; Antiestrogen; Histone deacetylase inhibitor; Bifunctional; In vitro; HDAC6; Biochemistry; Pharmacology; Histone; Cancer; Gene; Breast cancer; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002197838,0.0003827908,0.0002678329,0.0001930471,0.0001583059,0.0004142032,0.0006494478,0.0004379274,0.001137119],"category_scores_gemma":[0.0001372587,0.0002251,0.000311901,0.0001311971,0.0002624965,0.0005311412,0.0004679031,0.0005471913,0.0006134108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003385993,"about_ca_system_score_gemma":0.0002320538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003014659,"about_ca_topic_score_gemma":0.0006124192,"domain_scores_codex":[0.9999114,0.00001306599,0.000006449595,0.00002301599,0.00002166491,0.00002439941],"domain_scores_gemma":[0.9999518,0.000007607401,0.00001239892,0.000007452389,0.000009371123,0.00001131152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003336585,0.0001236967,0.0001776363,0.00019367,0.00004560734,0.0002300698,0.00007727397,0.002457059,0.956194,0.01368431,0.0004379207,0.02604513],"study_design_scores_gemma":[0.0001367621,0.002463106,0.0004047778,0.00002508496,0.00009748004,0.000474863,0.00004041246,0.006334349,0.9520004,0.002267397,0.03570618,0.00004910076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7608456,0.006630335,0.1999022,0.001384525,0.0003807067,0.0004063504,0.0004609944,0.0006881881,0.02930112],"genre_scores_gemma":[0.938306,0.002869051,0.04976855,0.0004912123,0.00004778437,0.0002100284,0.0002547589,0.00005270169,0.007999836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137119,"threshold_uncertainty_score":0.003804028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02791684449720081,"score_gpt":0.3177137298851036,"score_spread":0.2897968853879028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}