{"id":"W2883559266","doi":"10.1136/jmedgenet-2018-105472","title":"Evolution of genetic assessment for BRCA-associated gynaecologic malignancies: a Canadian multisociety roadmap","year":2018,"lang":"en","type":"review","venue":"Journal of Medical Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Jewish General Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Children's Hospital of Eastern Ontario; Winnipeg Regional Health Authority; BC Cancer Agency; Alberta Children's Hospital; London Health Sciences Centre; North York General Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; University of Manitoba; Juravinski Cancer Centre; Université de Montréal; Nova Scotia Health Authority; Princess Margaret Cancer Centre; CancerCare Manitoba; University Health Network; Ottawa Hospital; University of Toronto; St. John’s Health Sciences Centre","funders":"Partenariat Canadien Contre Le Cancer; Ovarian Cancer Canada; Sanofi; AstraZeneca; Pfizer","keywords":"Genetic testing; Genetic counseling; Ovarian cancer; Olaparib; Medicine; Precision medicine; Personalized medicine; Cancer; Oncology; Bioinformatics; Gynecology; Biology; Internal medicine; Genetics; Pathology; Gene; Polymerase; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004133944,0.0006955767,0.0008444826,0.004798106,0.001032192,0.001552354,0.001822069,0.001892512,0.00283159],"category_scores_gemma":[0.005821116,0.0003036206,0.0006121087,0.004618573,0.001901285,0.001462147,0.001251319,0.00372599,0.0007323732],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01563171,"about_ca_system_score_gemma":0.03307573,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3282751,"about_ca_topic_score_gemma":0.4525814,"domain_scores_codex":[0.9985033,0.00022251,0.0001474349,0.0001567074,0.0008134935,0.0001565682],"domain_scores_gemma":[0.9937544,0.001466432,0.0002554321,0.00009105697,0.003835359,0.0005972587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005108847,0.00004243656,0.001257571,0.006425126,0.00005745823,0.0005388683,0.0003356142,0.0004401503,0.0004783565,0.01104993,0.08423643,0.8950871],"study_design_scores_gemma":[0.00001026091,0.00002745156,0.002186361,0.004656081,0.00005745794,0.001081776,0.000157694,0.0001050361,0.0001664244,0.001595709,0.9899311,0.00002467834],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001918955,0.9873304,0.0003330167,0.008044526,0.0007761315,0.00001569444,0.00005104198,0.00001630345,0.003241001],"genre_scores_gemma":[0.001880033,0.9938911,0.00076441,0.001997828,0.00033358,0.000008466695,0.00006552655,0.000005758492,0.001053327],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9843683,"threshold_uncertainty_score":0.6527286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03205259647203992,"score_gpt":0.3624241327575028,"score_spread":0.3303715362854629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}