{"id":"W2883573930","doi":"10.1038/s41588-018-0147-3","title":"Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals","year":2018,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2846,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Toronto","funders":"National Institute on Aging; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Economic and Social Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Lundbeckfonden; Karolinska Institutet; National Institute for Health and Care Research; Novo Nordisk Fonden; Open Philanthropy Project; National Institutes of Health; National Institute of Mental Health; Vetenskapsrådet; Wellcome Trust","keywords":"Genome-wide association study; Biology; Single-nucleotide polymorphism; Educational attainment; Multifactorial Inheritance; Heritability; Genetic association; Genetics; SNP; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00215929,0.0008114916,0.001303053,0.002716465,0.0002460622,0.0009202163,0.001055687,0.00131994,0.001828995],"category_scores_gemma":[0.004217122,0.0003166792,0.0006951003,0.001706771,0.0007084055,0.0008213421,0.0007233511,0.001712267,0.001223322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007989632,"about_ca_system_score_gemma":0.001596766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002204286,"about_ca_topic_score_gemma":0.002814319,"domain_scores_codex":[0.9995167,0.0001328654,0.00007129876,0.0001247823,0.0001287634,0.00002561507],"domain_scores_gemma":[0.9979848,0.001360502,0.0001647851,0.00005562858,0.0003567834,0.00007756806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001267075,0.00002947157,0.002274619,0.007968482,0.0005574221,0.0003031487,0.000059348,0.0004284208,0.0005299703,0.006488699,0.0198202,0.9614135],"study_design_scores_gemma":[0.00008584007,0.0001607927,0.01277376,0.008567553,0.001375681,0.003412575,0.0001040899,0.0005550723,0.000985268,0.01519363,0.9566981,0.00008765951],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002134202,0.9977294,0.0005108056,0.0008381191,0.0001882633,0.000004877538,0.00004821267,0.000009941601,0.0004570312],"genre_scores_gemma":[0.001863215,0.9963712,0.0005678605,0.0004130591,0.0002645462,0.00001007387,0.00009997137,0.00000340254,0.0004067012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002716465,"threshold_uncertainty_score":0.01141953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319188078623464,"score_gpt":0.303236703263849,"score_spread":0.2900448224776144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}