{"id":"W2883601101","doi":"10.1101/368928","title":"<i>CNTN5</i> <sup>−/+</sup> or <i>EHMT2</i> <sup>−/+</sup> iPSC-Derived Neurons from Individuals with Autism Develop Hyperactive Neuronal Networks","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; McMaster University; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Induced pluripotent stem cell; Reprogramming; Autism; Autism spectrum disorder; Biology; Proband; Neuroscience; Polygenic risk score; Genetics; Psychology; Gene; Embryonic stem cell; Mutation; Developmental psychology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003140392,0.0003499016,0.0002168436,0.0003264635,0.0003415686,0.0002690733,0.0003371937,0.0002312867,0.002541696],"category_scores_gemma":[0.0001691819,0.0001178634,0.0002545782,0.0001975079,0.0003067185,0.0001096484,0.0003168662,0.0004346613,0.0004125632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002916499,"about_ca_system_score_gemma":0.0001808782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001410214,"about_ca_topic_score_gemma":0.003134737,"domain_scores_codex":[0.9997392,0.0000354979,0.0000455759,0.00007138125,0.0000832144,0.00002521681],"domain_scores_gemma":[0.9998448,0.00003989544,0.0000315667,0.00003766742,0.00002032305,0.00002568315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008599744,0.00003754285,0.001351985,0.00002915387,0.00001631026,0.0001535029,0.00004032668,0.0002255989,0.9962968,0.0002033651,0.00009441837,0.001465042],"study_design_scores_gemma":[0.00004518454,0.0002806703,0.02072683,0.00001570425,0.00006612542,0.001389059,0.00006762077,0.002676057,0.9687948,0.0001818837,0.005746447,0.000009551843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812858,0.0002193445,0.01308227,0.00006849883,0.00003027793,0.0002641761,0.002572034,0.0001261345,0.002351512],"genre_scores_gemma":[0.981764,0.0002019188,0.01171505,0.00009107774,0.000007731109,0.0002988797,0.003268683,0.0001233634,0.002529374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002541696,"threshold_uncertainty_score":0.008502781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0254335922296351,"score_gpt":0.2467754584920294,"score_spread":0.2213418662623944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}