{"id":"W2883621329","doi":"10.15252/emmm.201708084","title":"mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels","year":2018,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute on Aging; National Eye Institute; Leonard M. Miller School of Medicine; National Institutes of Health; United Mitochondrial Disease Foundation; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; University of Miami; Natural Sciences and Engineering Research Council of Canada; Muscular Dystrophy Association; National Institute of Neurological Disorders and Stroke; American Heart Association","keywords":"Mitochondrial DNA; DNA; Mutant; Enzyme; Molecular biology; Chemistry; Biology; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005758398,0.0005969575,0.0005348893,0.0004871083,0.0002480245,0.0006202366,0.0007078156,0.0008836911,0.001667606],"category_scores_gemma":[0.0003946177,0.0002550115,0.0003335229,0.0002692018,0.0003564876,0.0003446805,0.000569934,0.0009432143,0.0004339429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003290093,"about_ca_system_score_gemma":0.0001580106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002409912,"about_ca_topic_score_gemma":0.000464509,"domain_scores_codex":[0.9994168,0.00007631251,0.00004765865,0.000135814,0.0002525308,0.00007086938],"domain_scores_gemma":[0.9998038,0.00005259127,0.00005845991,0.00002751677,0.00002321231,0.00003444103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002678379,0.00001902939,0.0000561314,0.0000463402,0.000009460285,0.00003042326,0.0000155928,0.0001034926,0.9977842,0.0001560315,0.00004698128,0.001705527],"study_design_scores_gemma":[0.000007292659,0.0001365928,0.0003162041,0.000004159439,0.00001507118,0.0001793688,0.000008417671,0.0004490954,0.9957895,0.00003776473,0.003050652,0.000005917468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8849787,0.003508361,0.1047458,0.0002419859,0.0001175936,0.000296146,0.0005564915,0.001286971,0.004267859],"genre_scores_gemma":[0.9381989,0.001294841,0.04857856,0.0001661443,0.00002126157,0.0002013869,0.001079913,0.0002397792,0.01021936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001667606,"threshold_uncertainty_score":0.005578756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737224038580991,"score_gpt":0.2790352123463827,"score_spread":0.2616629719605728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}