{"id":"W2883621329","doi":"10.15252/emmm.201708084","title":"mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels","year":2018,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute on Aging; National Eye Institute; Leonard M. Miller School of Medicine; National Institutes of Health; United Mitochondrial Disease Foundation; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; University of Miami; Natural Sciences and Engineering Research Council of Canada; Muscular Dystrophy Association; National Institute of Neurological Disorders and Stroke; American Heart Association","keywords":"Mitochondrial DNA; DNA; Mutant; Enzyme; Molecular biology; Chemistry; Biology; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002798967,0.0003872666,0.0004433136,0.0001855016,0.0001741359,0.00002238768,0.0003899005,0.0003121343,0.0007781577],"category_scores_gemma":[0.001083585,0.0003532016,0.000144806,0.0004150866,0.0003347567,0.000006562328,0.0001957897,0.0002090314,0.0002798729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003380088,"about_ca_system_score_gemma":0.0001208273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003748991,"about_ca_topic_score_gemma":0.00002547533,"domain_scores_codex":[0.9973634,0.0002025404,0.0005360229,0.0009189135,0.0003651167,0.0006139776],"domain_scores_gemma":[0.9982856,0.00002516537,0.0001675057,0.0008316939,0.0002619755,0.0004280655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002331664,0.00004110378,0.00001720219,0.00001177023,0.00006522364,0.00007771674,0.0002646107,0.000008774276,0.9667788,0.0001304208,0.03012967,0.002241585],"study_design_scores_gemma":[0.001449164,0.001599663,0.0001356847,0.00005447,0.00005090559,0.0001755885,0.0001457884,0.00002646036,0.7485152,0.00007081428,0.2474639,0.000312294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8834876,0.0007713959,0.08745941,0.004507708,0.01024714,0.0008599723,0.00003923987,0.0000914027,0.01253613],"genre_scores_gemma":[0.9635642,0.00002668492,0.005273859,0.008489213,0.01926793,0.000103358,0.0002022939,0.0001042786,0.002968252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2182635,"threshold_uncertainty_score":0.999892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737224038580991,"score_gpt":0.2790352123463827,"score_spread":0.2616629719605728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}