{"id":"W2883622734","doi":"10.1038/s41467-018-04951-w","title":"Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes","year":2018,"lang":"en","type":"review","venue":"Nature Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1015,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute of Environmental Health Sciences; National Institute on Aging; National Institute of General Medical Sciences; National Institute of Mental Health; Medical Research Council; National Institutes of Health; University of Queensland; National Health and Medical Research Council; Wellcome Trust","keywords":"Genome-wide association study; Biology; Epigenomics; Genetics; DNA methylation; Genetic association; Expression quantitative trait loci; Epigenetics; Gene; Computational biology; Type 2 diabetes; Genome; Single-nucleotide polymorphism; Gene expression; Genotype; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001345298,0.0003005309,0.0007929683,0.0001259702,0.0004656129,0.00004570428,0.0007542945,0.001564292,0.000005369223],"category_scores_gemma":[0.005897795,0.0002758841,0.0003193804,0.0002517513,0.0001054314,0.000005737237,0.0004697179,0.0005825538,0.00001486766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268743,"about_ca_system_score_gemma":0.0002147664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006172859,"about_ca_topic_score_gemma":0.00007634289,"domain_scores_codex":[0.9976487,0.0009264395,0.0005395519,0.0004717875,0.0001130422,0.0003005191],"domain_scores_gemma":[0.9956623,0.001189989,0.001129378,0.00137426,0.0005675111,0.00007661583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001127895,0.001764078,0.1004087,0.01003578,0.05255152,0.000001993312,0.001025795,0.00007169149,0.003319594,0.00561268,0.3410545,0.4840409],"study_design_scores_gemma":[0.000158012,0.0001244893,0.02104121,0.0001626588,0.001686181,9.769885e-7,0.00002456412,0.00003302755,0.00001985463,0.002038014,0.9743707,0.000340282],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00081043,0.9962352,0.0009228494,0.000202774,0.0002912948,0.0007024306,0.0006489484,0.00001807988,0.0001679968],"genre_scores_gemma":[0.005739364,0.9732895,0.01446355,0.0002207467,0.0001959954,0.0002274611,0.005284467,0.00005070907,0.0005281376],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6333162,"threshold_uncertainty_score":0.9999694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06433862523022009,"score_gpt":0.4095248460243476,"score_spread":0.3451862207941275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}