{"id":"W2883630601","doi":"10.1007/s40261-018-0672-y","title":"The Effect of Food on Tramadol and Celecoxib Bioavailability Following Oral Administration of Co-Crystal of Tramadol–Celecoxib (CTC): A Randomised, Open-Label, Single-Dose, Crossover Study in Healthy Volunteers","year":2018,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Veterinary Pharmacology and Anesthesia","field":"Veterinary","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada); Innovaderm (Canada)","funders":"Esteve Pharmaceuticals","keywords":"Celecoxib; Medicine; Cmax; Tramadol; Bioavailability; Pharmacokinetics; Crossover study; Pharmacology; Oral administration; Bioequivalence; Analgesic; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001170793,0.001229622,0.002418578,0.000397619,0.0005846897,0.0007547195,0.0005356332,0.001673106,0.003183493],"category_scores_gemma":[0.002334412,0.001148936,0.001343194,0.0003551801,0.001433182,0.001046629,0.0005022397,0.00199594,0.0006896533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004503679,"about_ca_system_score_gemma":0.0008488533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069952,"about_ca_topic_score_gemma":0.001427373,"domain_scores_codex":[0.9991087,0.0003180224,0.00006905354,0.0002253902,0.0001171396,0.000161575],"domain_scores_gemma":[0.998242,0.0005170394,0.0003590329,0.0001811092,0.0001650278,0.0005357465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9241831,0.02510595,0.0009349734,0.0002825686,0.0002564703,0.00009249349,0.0001576926,0.0001544206,0.03923177,0.00003749087,0.0001792903,0.009383895],"study_design_scores_gemma":[0.09799416,0.8785219,0.01453233,0.00001397712,0.0004216309,0.0001036854,0.00007350762,0.0004690356,0.007213362,0.00005995559,0.0005520758,0.00004443186],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983468,0.0004775721,0.000177082,0.00004609575,0.00008466807,0.0004508477,0.0001510106,0.0000215512,0.0002444491],"genre_scores_gemma":[0.9958283,0.0006206571,0.000705163,0.0001531635,0.0001939496,0.0005877095,0.0003391979,0.00002030905,0.001551593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003183493,"threshold_uncertainty_score":0.0106498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1405574194173126,"score_gpt":0.4416549860913744,"score_spread":0.3010975666740618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}