{"id":"W2883630601","doi":"10.1007/s40261-018-0672-y","title":"The Effect of Food on Tramadol and Celecoxib Bioavailability Following Oral Administration of Co-Crystal of Tramadol–Celecoxib (CTC): A Randomised, Open-Label, Single-Dose, Crossover Study in Healthy Volunteers","year":2018,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Veterinary Pharmacology and Anesthesia","field":"Veterinary","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada); Innovaderm (Canada)","funders":"Esteve Pharmaceuticals","keywords":"Celecoxib; Medicine; Cmax; Tramadol; Bioavailability; Pharmacokinetics; Crossover study; Pharmacology; Oral administration; Bioequivalence; Analgesic; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006043034,0.0002745904,0.0008957659,0.00009575494,0.0002075045,0.00004276588,0.0003942537,0.0002174393,0.00001938868],"category_scores_gemma":[0.001273155,0.0002136381,0.0001546914,0.0002973377,0.00149215,0.0002951515,0.00009112478,0.0004066393,0.000004976367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005590514,"about_ca_system_score_gemma":0.0001864618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001160973,"about_ca_topic_score_gemma":0.0002666421,"domain_scores_codex":[0.9938753,0.003138568,0.00183274,0.000553117,0.0002971036,0.0003032309],"domain_scores_gemma":[0.99536,0.003243884,0.0007289736,0.0004109944,0.0001014781,0.000154733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4278657,0.008041603,0.4341361,0.0007643233,0.0005405616,0.00007441109,0.003378726,0.00001041633,0.1145528,0.0001440742,0.0004025201,0.01008886],"study_design_scores_gemma":[0.1709924,0.3442452,0.4267979,0.0004803287,0.000436505,0.00006026109,0.0007442045,0.002757586,0.05171375,0.0008570927,0.0002535495,0.0006612427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962118,0.00007255868,0.000008116506,0.0002564226,0.0002956099,0.003014975,0.00002402789,0.00002300823,0.00009343694],"genre_scores_gemma":[0.999438,0.000008807016,0.000169819,0.0001407034,0.00006596464,0.0001106461,0.00001967773,0.00002529136,0.00002106577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3362036,"threshold_uncertainty_score":0.871191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1405574194173126,"score_gpt":0.4416549860913744,"score_spread":0.3010975666740618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}