{"id":"W2883696801","doi":"10.1038/s41598-018-29486-4","title":"Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Birth, Development, and Health","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Canadian Institute for Advanced Research","funders":"National Institute of Environmental Health Sciences; Natural Sciences and Engineering Research Council of Canada; National Center for Research Resources; Wenner-Gren Foundation; National Institutes of Health; National Science Foundation","keywords":"Telomere; Cellular Aging; Epigenetics; Reproduction; Biology; Senescence; DNA methylation; Somatic cell; Biomarker; Physiology; Longevity; Fertility; Ageing; Offspring; Biological age; Andrology; Cohort; Pregnancy; Mutation Accumulation; Genetics; Gene; Medicine; Evolutionary biology; Internal medicine; Gene expression; Population; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002672083,0.0001273055,0.0001081023,0.0003509237,0.0001974283,0.0003192069,0.0001395699,0.0002564173,0.002909264],"category_scores_gemma":[0.001811425,0.0001159244,0.0001609228,0.0003129409,0.0001687522,0.0001631323,0.0002055389,0.0003016067,0.0002481399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009425207,"about_ca_system_score_gemma":0.0001483338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002575026,"about_ca_topic_score_gemma":0.003545465,"domain_scores_codex":[0.999935,0.00001464588,0.000004982415,0.00002074413,0.000009073924,0.00001547798],"domain_scores_gemma":[0.9994312,0.0001427541,0.0002715404,0.00005210334,0.000027603,0.00007475348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008590038,0.00001038019,0.9975004,0.00000503499,0.00001434432,0.00002958703,0.00004697002,0.00001549864,0.000337115,0.00002304959,0.00004437725,0.001887409],"study_design_scores_gemma":[0.000001023492,0.00002801242,0.9995996,0.000002204792,0.00001247691,0.00007768971,0.00005382667,0.00006298283,0.00006019001,0.00002805964,0.00007302542,8.561955e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988639,0.0002995198,0.0000667905,0.00006827293,0.000004990752,0.000002083699,0.0001310097,0.00000283484,0.0005606325],"genre_scores_gemma":[0.9995673,0.0001260901,0.00003584559,0.00001105418,0.000007019013,0.000001489667,0.00005043848,6.537135e-7,0.000200123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002909264,"threshold_uncertainty_score":0.009732485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119297679212848,"score_gpt":0.2756011516464204,"score_spread":0.2544081748542919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}