{"id":"W2883696801","doi":"10.1038/s41598-018-29486-4","title":"Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Birth, Development, and Health","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Canadian Institute for Advanced Research","funders":"National Institute of Environmental Health Sciences; Natural Sciences and Engineering Research Council of Canada; National Center for Research Resources; Wenner-Gren Foundation; National Institutes of Health; National Science Foundation","keywords":"Telomere; Cellular Aging; Epigenetics; Reproduction; Biology; Senescence; DNA methylation; Somatic cell; Biomarker; Physiology; Longevity; Fertility; Ageing; Offspring; Biological age; Andrology; Cohort; Pregnancy; Mutation Accumulation; Genetics; Gene; Medicine; Evolutionary biology; Internal medicine; Gene expression; Population; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001492493,0.0001318466,0.0002062765,0.0002141611,0.0004892942,0.0001862624,0.0000394189,0.00009101201,0.0001954252],"category_scores_gemma":[0.0002963591,0.000111913,0.00002624154,0.0003455022,0.0005009432,0.0002100597,0.00004372651,0.0001169666,0.00001978755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001306237,"about_ca_system_score_gemma":0.0002754937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009235705,"about_ca_topic_score_gemma":0.0003000048,"domain_scores_codex":[0.9976383,0.00003189342,0.0005166122,0.0009561563,0.0004801748,0.0003768068],"domain_scores_gemma":[0.9983779,0.000005661488,0.0002160084,0.0007235974,0.0003610273,0.0003158094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006082432,0.0001223721,0.9101041,0.0002369116,0.00004524897,0.0004440951,0.01336788,6.551627e-7,0.03078803,0.0002016428,0.03210765,0.01252056],"study_design_scores_gemma":[0.0002669329,0.0001869914,0.9647855,0.0000975143,0.00002784257,0.000743602,0.0005449071,0.0000642862,0.01910447,0.009083571,0.004926824,0.0001675793],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870822,0.000107685,0.0001003331,0.0003028144,0.005414323,0.0005881129,7.195034e-7,0.0001019632,0.006301827],"genre_scores_gemma":[0.9944643,0.0005371295,0.0006821679,0.0001468768,0.0005881632,0.00004976117,0.00005803548,0.00001701952,0.003456481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05468135,"threshold_uncertainty_score":0.4563679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119297679212848,"score_gpt":0.2756011516464204,"score_spread":0.2544081748542919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}