{"id":"W2883745175","doi":"10.1016/j.dnarep.2018.07.005","title":"DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications","year":2018,"lang":"en","type":"review","venue":"DNA repair","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acadia University","funders":"","keywords":"DNA damage; Biology; DNA repair; Colorectal cancer; Cancer research; Signal transduction; Cancer; Cell cycle checkpoint; Apoptosis; Kinase; Genome instability; Cell cycle; DNA mismatch repair; Bioinformatics; Cell biology; DNA; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007263882,0.000344028,0.001053506,0.0002954692,0.0001084222,0.00001769379,0.00006823576,0.0003343865,0.00007898727],"category_scores_gemma":[0.00006538412,0.0002854681,0.0003047246,0.0004158752,0.0001406372,0.00004791341,0.00005600803,0.0002598251,0.00000676069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003315864,"about_ca_system_score_gemma":0.0004604814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001076656,"about_ca_topic_score_gemma":0.0003085184,"domain_scores_codex":[0.9981501,0.0002867163,0.0004908678,0.0006546333,0.0001502782,0.0002674156],"domain_scores_gemma":[0.9988087,0.0002482664,0.0002317676,0.0005007552,0.00007203732,0.0001384881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002459303,0.0002589239,0.001354711,0.01347228,0.0009366444,0.00007210452,0.0009832628,2.040513e-7,0.002672215,0.002819179,0.004117309,0.9708539],"study_design_scores_gemma":[0.0008539867,0.000545795,0.02479973,0.004689637,0.0006458414,0.0001509973,0.00002047208,0.00006273288,0.00005869834,0.0003752561,0.9674877,0.0003091833],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06866451,0.9288444,0.00000603758,0.0002488674,0.0001320877,0.001603144,0.0001008341,0.0002770204,0.0001231079],"genre_scores_gemma":[0.002247283,0.9958625,0.000264344,0.0002444129,0.0002124591,0.0005249095,0.00006806265,0.00007841783,0.0004976235],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9705447,"threshold_uncertainty_score":0.9999598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03612270118145772,"score_gpt":0.3440194544074142,"score_spread":0.3078967532259565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}