{"id":"W2883753017","doi":"10.1093/abbs/gmy081","title":"HDL impairs osteoclastogenesis and induces osteoclast apoptosis via upregulation of ABCG1 expression","year":2018,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Alberta; University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Osteoclast; Chemistry; Gene knockdown; Cholesterol; Efflux; ABCG1; Cell biology; Tartrate-resistant acid phosphatase; Apoptosis; Reverse cholesterol transport; ABCA1; Internal medicine; Endocrinology; Biology; Biochemistry; Lipoprotein; Medicine; Transporter; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723218,0.0002309454,0.0002910547,0.0002745381,0.0001499333,0.0002486328,0.0001242724,0.0002678391,0.001339238],"category_scores_gemma":[0.0001402024,0.0001248771,0.0003125684,0.0002342024,0.0002475388,0.0001276015,0.0002182171,0.0006082617,0.0001813954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576962,"about_ca_system_score_gemma":0.0003261903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00139059,"about_ca_topic_score_gemma":0.001659131,"domain_scores_codex":[0.9998248,0.00003048479,0.0000173767,0.00001762182,0.00005461872,0.00005515188],"domain_scores_gemma":[0.9999254,0.0000137905,0.00002144184,0.000008946196,0.00001284336,0.00001754755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005969983,0.0001134951,0.00147021,0.0001533069,0.00002132363,0.0002219201,0.00002685329,0.00006012103,0.9913929,0.0002078077,0.0001858904,0.005549411],"study_design_scores_gemma":[0.0003695385,0.001635504,0.04278855,0.00003019132,0.0001267773,0.001067178,0.0001071276,0.001323195,0.944967,0.0003274945,0.007242428,0.00001520389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917933,0.004886813,0.001411653,0.0002118765,0.00005657624,0.00002565378,0.0002338862,0.00009637306,0.001283743],"genre_scores_gemma":[0.9957013,0.001695727,0.0005039045,0.000107918,0.00001268043,0.00002538956,0.0002531192,0.00000754087,0.001692425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139059,"threshold_uncertainty_score":0.004480183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008224592451248234,"score_gpt":0.2465798114472296,"score_spread":0.2383552189959813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}