{"id":"W2883766009","doi":"10.1097/01.tp.0000542859.38902.af","title":"“First-In-Human” Clinical Trial Employing Adoptive Transfer of Autologous Thymus-Derived Treg Cells (thyTreg) to Prevent Graft Rejection in Heart-Transplanted Children","year":2018,"lang":"en","type":"article","venue":"Transplantation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; CNIB Foundation","funders":"","keywords":"FOXP3; Adoptive cell transfer; IL-2 receptor; Medicine; Immune system; Immunology; Clinical trial; Immunotherapy; Cell therapy; Transplantation; T cell; Cell; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003413304,0.001023067,0.001418434,0.0002277382,0.0004242278,0.000976783,0.0008696599,0.001290076,0.003137273],"category_scores_gemma":[0.0008140443,0.0002555029,0.0007906728,0.0001878893,0.0008733852,0.0007086438,0.0004138401,0.00291645,0.0006983505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003971001,"about_ca_system_score_gemma":0.0008685854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001308601,"about_ca_topic_score_gemma":0.0002923727,"domain_scores_codex":[0.9988483,0.0005420024,0.0000801936,0.0001671139,0.0001827107,0.0001797793],"domain_scores_gemma":[0.9994689,0.0001045078,0.0000963123,0.00009268299,0.00005810866,0.0001795564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.07984104,0.06308635,0.007256701,0.004303321,0.001349874,0.001256973,0.0006288652,0.001838874,0.610152,0.001858356,0.01102092,0.2174067],"study_design_scores_gemma":[0.0510671,0.6315435,0.01011422,0.000450161,0.001120589,0.002203151,0.0002004651,0.001054177,0.2604823,0.000753515,0.04094595,0.00006495191],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572895,0.01521999,0.01160431,0.001509206,0.0008409693,0.006821067,0.001960603,0.0003161533,0.004438316],"genre_scores_gemma":[0.959681,0.009129443,0.01483481,0.002600865,0.00059505,0.004889026,0.004235326,0.0001067172,0.003927821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003413304,"threshold_uncertainty_score":0.01805151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02435097815201568,"score_gpt":0.3040832279042427,"score_spread":0.279732249752227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}