{"id":"W2883776632","doi":"10.15252/embr.201745000","title":"KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control","year":2018,"lang":"en","type":"article","venue":"EMBO Reports","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Royal Society; University College London; European Research Council; Cancer Research UK; Wellcome Trust","keywords":"Endogenous retrovirus; Biology; Innate immune system; Gene; CpG site; Zinc finger; DNA methylation; Epigenetics; Genome; Immune system; Interferon; Genetics; Cell biology; Gene expression; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213681,0.0001528749,0.0001341129,0.0002560789,0.0001113974,0.0004077418,0.0001358208,0.0001957463,0.002305876],"category_scores_gemma":[0.0001680557,0.0001061475,0.0001238883,0.0001288939,0.0001442351,0.000147517,0.0002102619,0.0002794117,0.0006749742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528741,"about_ca_system_score_gemma":0.0001609529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003067977,"about_ca_topic_score_gemma":0.0002718292,"domain_scores_codex":[0.9998978,0.00001549594,0.000008258672,0.00002717556,0.00002670989,0.00002461292],"domain_scores_gemma":[0.9999056,0.00001305817,0.00003668878,0.00000924112,0.00001423066,0.00002120395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001923441,0.00001437905,0.001443764,0.00005551631,0.000006213426,0.0001423017,0.00003344141,0.00006952104,0.9918642,0.0003036696,0.0001152279,0.005759332],"study_design_scores_gemma":[0.00001825884,0.0001809165,0.03147916,0.00002612611,0.00002486446,0.002099198,0.00009063489,0.001112276,0.9522075,0.0003740915,0.01237735,0.000009613954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813322,0.01059372,0.003696638,0.0001171702,0.0000255334,0.00001960079,0.0007339894,0.0001862255,0.003294939],"genre_scores_gemma":[0.9935407,0.001921491,0.001346553,0.00003919351,0.000006596134,0.00001153934,0.0006094471,0.00002016753,0.002504231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002305876,"threshold_uncertainty_score":0.007713914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009877845171170291,"score_gpt":0.2443713505824667,"score_spread":0.2344935054112964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}