{"id":"W2883778176","doi":"10.1038/s41422-018-0066-y","title":"Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta ","year":2018,"lang":"en","type":"article","venue":"Cell Research","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":428,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Cytotrophoblast; Biology; Placentation; Trophoblast; Placenta; RNA; Cellular differentiation; Cell; Cell biology; Gene; Immunology; Pregnancy; Fetus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008501699,0.00005897717,0.0001462633,0.0000785455,0.0002515172,0.00000800845,0.0001901332,0.00004111355,0.00005990444],"category_scores_gemma":[0.00006361815,0.00003284264,0.00003052023,0.0001465175,0.0003454346,0.00002681508,0.0003419379,0.0002193693,0.000003405222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002144158,"about_ca_system_score_gemma":0.00001487541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000356268,"about_ca_topic_score_gemma":0.0002871065,"domain_scores_codex":[0.9988412,0.0003122388,0.0001422786,0.000128314,0.0003978931,0.0001780291],"domain_scores_gemma":[0.9991236,0.0004017047,0.0000553182,0.000266652,0.0001286133,0.00002414061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001712336,0.0002910163,0.831535,0.0004057158,0.00001758193,0.000003999196,0.01190407,8.233806e-8,0.1541944,0.00009719291,0.000874349,0.0005053382],"study_design_scores_gemma":[0.000999878,0.0006241357,0.827845,0.000239189,0.00002619099,9.748438e-7,0.002897409,0.000009971511,0.1667848,0.0004033158,0.0001294871,0.00003962972],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894456,0.0006775243,0.000008143108,0.0003239629,0.00002146066,0.0003182557,0.000008832955,0.000002785709,0.00919346],"genre_scores_gemma":[0.9988753,0.0002829072,0.000006512186,0.00002379508,0.00004697611,0.000004726675,0.000004096486,0.000004263043,0.0007514904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01259038,"threshold_uncertainty_score":0.1934492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09728065856588815,"score_gpt":0.3313701811656173,"score_spread":0.2340895225997292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}