{"id":"W2883811505","doi":"10.1101/372524","title":"YB-1 IS REQUIRED FOR THE GENESIS AND METASTATIC CAPACITY OF HUMAN BREAST CANCER","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Terry Fox Research Institute; Michael Smith Health Research BC; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Human breast; Gene knockdown; Cancer; Downregulation and upregulation; Breast cancer; Cell culture; CA15-3; KRAS; Ductal carcinoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009562997,0.0001427356,0.0001554046,0.0001349305,0.0001586498,0.0002479635,0.00007642946,0.0001514583,0.001502648],"category_scores_gemma":[0.0001318688,0.0001110489,0.0001075221,0.0001095941,0.00015611,0.0000697026,0.0001445073,0.0003086981,0.000530064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260609,"about_ca_system_score_gemma":0.0002596061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001093946,"about_ca_topic_score_gemma":0.0009443221,"domain_scores_codex":[0.9999262,0.000007620443,0.000006307107,0.00001734753,0.00002268419,0.00001989439],"domain_scores_gemma":[0.9999307,0.000007071819,0.00002488281,0.000009137347,0.00001188081,0.00001617121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060139,0.000008914444,0.0007738481,0.00001935886,0.000003078838,0.00008925184,0.00001222591,0.00003417393,0.9977182,0.0001088185,0.00009047788,0.001035714],"study_design_scores_gemma":[0.00001647046,0.0001260751,0.03720614,0.000007887267,0.00001500641,0.001082572,0.00005562126,0.0006814668,0.9553719,0.0001566423,0.005276234,0.000003981884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952202,0.001825953,0.001080222,0.000159773,0.00002119144,0.000008709098,0.0005773605,0.00006751737,0.001038933],"genre_scores_gemma":[0.9969758,0.0004044524,0.0004730574,0.00002273549,0.000006509478,0.000006047167,0.0006433585,0.00001446718,0.00145352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001502648,"threshold_uncertainty_score":0.005026817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0308535129477917,"score_gpt":0.2808307886873085,"score_spread":0.2499772757395168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}