{"id":"W2883813435","doi":"10.1158/0008-5472.can-18-0951","title":"A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; BC Cancer Agency; Princess Margaret Cancer Centre; University of British Columbia; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Medical Research and Materiel Command; National Center for Advancing Translational Sciences; National Center for Research Resources; NIHR Cambridge Biomedical Research Centre; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Health Canada; National Institutes of Health; BC Cancer Foundation; Hebei Medical University; Pomorski Uniwersytet Medyczny W Szczecinie; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; Institut Gustave-Roussy; Norges Forskningsråd; Helse Vest; Japan Society for the Promotion of Science; Hellenic Health Foundation; Ministry of Health, Labour and Welfare; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Associazione Italiana per la Ricerca sul Cancro; Canadian HIV Trials Network, Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; Cancerfonden; National Cancer Institute; Peter MacCallum Foundation; University College London; Cancer Institute NSW; European Commission; Fred C. and Katherine B. Andersen Foundation; University of Cambridge; Roswell Park Cancer Institute; National Institute for Health and Care Research; Swedish Cancer Foundation; Ovarian Cancer Australia; U.S. Department of Defense; Cancer Research UK; World Health Organization; Wellcome Trust; Kreftforeningen; Cancer Research Society; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Vanderbilt University Medical Center; Deutsches Krebsforschungszentrum; Cancer Council Victoria; Kræftens Bekæmpelse; Mayo Foundation for Medical Education and Research; Radboud Universiteit; Lon V. Smith Foundation; European Social Fund; State of Connecticut Department of Public Health; Korea Health Industry Development Institute; Oregon Health and Science University; Minnesota Ovarian Cancer Alliance; Moffitt Cancer Center; Vanderbilt University; Rutgers Cancer Institute of New Jersey; Cancer Australia; Oak Foundation; NordForsk; Vetenskapsrådet; Georgia Clinical and Translational Science Alliance","keywords":"Transcriptome; Ovarian cancer; Candidate gene; Gene; Biology; Epithelial ovarian cancer; Cancer; Oncology; Genetics; Internal medicine; Bioinformatics; Computational biology; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005492113,0.0001754698,0.0004500066,0.0004065884,0.0004882102,0.0003681084,0.0002316261,0.0002590216,0.002427562],"category_scores_gemma":[0.001232526,0.0002203308,0.0004610234,0.001142852,0.0001801089,0.0001365816,0.0003550229,0.0003537398,0.000305762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001235604,"about_ca_system_score_gemma":0.0002048797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002099799,"about_ca_topic_score_gemma":0.003002514,"domain_scores_codex":[0.9996018,0.0000897306,0.0000296104,0.0001610237,0.00006954002,0.0000483902],"domain_scores_gemma":[0.9994596,0.0002170012,0.0001260486,0.000095395,0.00004658257,0.00005544916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003755803,0.00003881218,0.9863404,0.000028046,0.0003245517,0.0002917515,0.0000878928,0.0001893834,0.00868883,0.00005428818,0.0004541041,0.003126301],"study_design_scores_gemma":[0.00005247954,0.00006678005,0.9964349,0.000004258704,0.000188685,0.0004374999,0.000103984,0.000993158,0.0007160352,0.00009025729,0.0009080964,0.000003918658],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959352,0.0002131749,0.001115381,0.00004784828,0.000005856048,0.00001342996,0.002363811,0.00001707037,0.0002882961],"genre_scores_gemma":[0.9969667,0.00007626131,0.0005321022,0.00003713572,0.00000536494,0.00002478829,0.002121235,0.000009091331,0.0002272995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002427562,"threshold_uncertainty_score":0.008120954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0684549278744645,"score_gpt":0.4351848266239564,"score_spread":0.3667298987494919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}