{"id":"W2883813435","doi":"10.1158/0008-5472.can-18-0951","title":"A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; BC Cancer Agency; Princess Margaret Cancer Centre; University of British Columbia; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Medical Research and Materiel Command; National Center for Advancing Translational Sciences; National Center for Research Resources; NIHR Cambridge Biomedical Research Centre; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Health Canada; National Institutes of Health; BC Cancer Foundation; Hebei Medical University; Pomorski Uniwersytet Medyczny W Szczecinie; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; Institut Gustave-Roussy; Norges Forskningsråd; Helse Vest; Japan Society for the Promotion of Science; Hellenic Health Foundation; Ministry of Health, Labour and Welfare; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Associazione Italiana per la Ricerca sul Cancro; Canadian HIV Trials Network, Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; Cancerfonden; National Cancer Institute; Peter MacCallum Foundation; University College London; Cancer Institute NSW; European Commission; Fred C. and Katherine B. Andersen Foundation; University of Cambridge; Roswell Park Cancer Institute; National Institute for Health and Care Research; Swedish Cancer Foundation; Ovarian Cancer Australia; U.S. Department of Defense; Cancer Research UK; World Health Organization; Wellcome Trust; Kreftforeningen; Cancer Research Society; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Vanderbilt University Medical Center; Deutsches Krebsforschungszentrum; Cancer Council Victoria; Kræftens Bekæmpelse; Mayo Foundation for Medical Education and Research; Radboud Universiteit; Lon V. Smith Foundation; European Social Fund; State of Connecticut Department of Public Health; Korea Health Industry Development Institute; Oregon Health and Science University; Minnesota Ovarian Cancer Alliance; Moffitt Cancer Center; Vanderbilt University; Rutgers Cancer Institute of New Jersey; Cancer Australia; Oak Foundation; NordForsk; Vetenskapsrådet; Georgia Clinical and Translational Science Alliance","keywords":"Transcriptome; Ovarian cancer; Candidate gene; Gene; Biology; Epithelial ovarian cancer; Cancer; Oncology; Genetics; Internal medicine; Bioinformatics; Computational biology; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003494848,0.0002684246,0.0005744062,0.0003336591,0.0005907777,0.0001608831,0.0002730943,0.0001556311,0.001961577],"category_scores_gemma":[0.0006925917,0.0002299775,0.0001539513,0.0008603363,0.0001617496,0.0001593048,0.00008917466,0.0004049166,0.0001226812],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006142583,"about_ca_system_score_gemma":0.001037765,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.04362956,"about_ca_topic_score_gemma":0.05497668,"domain_scores_codex":[0.9957198,0.0004290752,0.0004659304,0.0009720783,0.001180641,0.001232483],"domain_scores_gemma":[0.996672,0.0004930436,0.0001397178,0.0006973144,0.00139626,0.0006016337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001783324,0.0008064975,0.953698,0.00009776979,0.000908454,0.00001551562,0.008690793,0.00000892876,0.005443186,0.000009128574,0.01004939,0.018489],"study_design_scores_gemma":[0.006455157,0.002645297,0.9425431,0.000140268,0.000265109,2.506011e-7,0.001564645,0.00001965421,0.01382271,0.0001775085,0.03212971,0.0002365281],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871917,0.0005365193,0.0001041832,0.005050591,0.0008135839,0.005174101,0.0008829865,0.00006446231,0.0001819213],"genre_scores_gemma":[0.9818761,0.0006937103,0.00009828444,0.0003865359,0.001861861,0.01114095,0.0000207827,0.00006949827,0.003852264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02208032,"threshold_uncertainty_score":0.9989508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0684549278744645,"score_gpt":0.4351848266239564,"score_spread":0.3667298987494919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}