{"id":"W2883891331","doi":"10.1016/j.bpj.2018.05.037","title":"Blebbistatin Effects Expose Hidden Secrets in the Force-Generating Cycle of Actin and Myosin","year":2018,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"H2020 Future and Emerging Technologies; Linnéuniversitetet; Vetenskapsrådet; Svenska Forskningsrådet Formas","keywords":"Myosin; ATP hydrolysis; Biophysics; Motility; Actin; Molecular motor; Muscle contraction; Myosin head; Chemistry; Contraction (grammar); Cell biology; Adenosine triphosphate; Biochemistry; Biology; Myosin light-chain kinase; Anatomy; ATPase; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000323531,0.0001054051,0.0002870232,0.00004923369,0.0001402342,0.00002943213,0.0000629471,0.000038435,0.000005721364],"category_scores_gemma":[0.0001656894,0.00006426563,0.00009401728,0.0001452629,0.000183987,0.00005947295,0.00004401435,0.0002330916,0.000003665128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002016957,"about_ca_system_score_gemma":0.00003024257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001623,"about_ca_topic_score_gemma":0.000004190498,"domain_scores_codex":[0.9991229,0.0001189816,0.0002155834,0.0001172937,0.0002405931,0.00018461],"domain_scores_gemma":[0.9994318,0.0002053077,0.00009907682,0.0001155138,0.00007780312,0.00007046212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002269518,0.000127109,0.002021748,0.0000717035,0.00006384527,0.0001408815,0.004792975,5.633077e-7,0.9666694,0.0002537614,0.0005831765,0.02504787],"study_design_scores_gemma":[0.007869695,0.004728843,0.3190846,0.001082144,0.0005099161,0.002342426,0.00640571,0.001381613,0.6537334,0.001219608,0.001185142,0.0004569211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979559,0.0001796094,0.0001392442,0.0005289215,0.0001339086,0.0001504836,0.000002257006,0.000006790311,0.0009028689],"genre_scores_gemma":[0.9975514,0.00004645494,0.000835898,0.0002913466,0.001213179,0.000005768277,9.919389e-7,0.00000909039,0.00004585744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3170629,"threshold_uncertainty_score":0.2620676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241699145114458,"score_gpt":0.2773372581647329,"score_spread":0.2649202667135884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}