{"id":"W2883911404","doi":"10.1002/art.40668","title":"Disease‐Modifying Osteoarthritis Treatment With Interleukin‐1 Receptor Antagonist Gene Therapy in Small and Large Animal Models","year":2018,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Cartilage; Medicine; Synovitis; Osteoarthritis; Lameness; Interleukin 1 receptor antagonist; Receptor antagonist; Pathology; Interleukin; Synovial fluid; Surgery; Urology; Internal medicine; Receptor; Antagonist; Arthritis; Cytokine; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001291979,0.0004601385,0.0008599528,0.0002477956,0.0002501491,0.00006116216,0.00009376726,0.0001800546,0.0003024405],"category_scores_gemma":[0.00001334078,0.0003931454,0.0001034164,0.0001993583,0.000405944,0.0002262197,0.00006676628,0.0001634105,0.0000796322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196766,"about_ca_system_score_gemma":0.000187444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001674718,"about_ca_topic_score_gemma":0.005580803,"domain_scores_codex":[0.9975989,0.0001181148,0.0004890604,0.0008060785,0.0001611718,0.000826608],"domain_scores_gemma":[0.9988577,0.00006292613,0.0001189772,0.0004384232,0.0001139907,0.0004079814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01315982,0.002051771,0.2679349,0.00009364077,0.0002430853,0.003048277,0.004407012,4.363245e-7,0.02094441,0.01153052,0.0001247673,0.6764613],"study_design_scores_gemma":[0.3745143,0.3201934,0.03464274,0.009615556,0.0004079616,0.02496737,0.004345163,0.001227525,0.145483,0.009744984,0.0699455,0.004912475],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982241,0.01474692,0.0001366337,0.0006744678,0.0002184171,0.001102704,0.0001255467,0.0001528429,0.0006014391],"genre_scores_gemma":[0.984732,0.01169851,0.002410579,0.0002875577,0.00007694179,0.0003186027,0.000196849,0.00008068375,0.0001982826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6715488,"threshold_uncertainty_score":0.9998521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037179155505051,"score_gpt":0.2478216082469678,"score_spread":0.2274498166919173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}