{"id":"W2883911404","doi":"10.1002/art.40668","title":"Disease‐Modifying Osteoarthritis Treatment With Interleukin‐1 Receptor Antagonist Gene Therapy in Small and Large Animal Models","year":2018,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Cartilage; Medicine; Synovitis; Osteoarthritis; Lameness; Interleukin 1 receptor antagonist; Receptor antagonist; Pathology; Interleukin; Synovial fluid; Surgery; Urology; Internal medicine; Receptor; Antagonist; Arthritis; Cytokine; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009562169,0.0008859053,0.0008938386,0.001025361,0.0003830002,0.000783326,0.0007426133,0.0008749719,0.002220534],"category_scores_gemma":[0.0002697889,0.0002861679,0.0006786369,0.0003765903,0.0007781346,0.0006843712,0.0002926995,0.001379629,0.0009107349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004324802,"about_ca_system_score_gemma":0.0005157332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005461563,"about_ca_topic_score_gemma":0.001116293,"domain_scores_codex":[0.9994475,0.0001331013,0.00005252612,0.0001006044,0.0001824627,0.0000838218],"domain_scores_gemma":[0.9996973,0.00004482783,0.0001012547,0.00005489137,0.00003879629,0.00006286291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007692668,0.001148136,0.0002465333,0.0003144173,0.00004601345,0.00009598555,0.0000384378,0.000188565,0.9858526,0.0004049568,0.000444577,0.01045033],"study_design_scores_gemma":[0.002157213,0.03246992,0.006001515,0.0002513074,0.0004828828,0.002151581,0.000145905,0.003176418,0.9114659,0.0004807007,0.0411555,0.0000611361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9029716,0.04143495,0.03980975,0.001845607,0.0008129588,0.001773423,0.001489418,0.001091065,0.008771306],"genre_scores_gemma":[0.923806,0.02848912,0.02798308,0.0004664594,0.0002478365,0.002710555,0.002022666,0.00008652741,0.01418781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002220534,"threshold_uncertainty_score":0.007428467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037179155505051,"score_gpt":0.2478216082469678,"score_spread":0.2274498166919173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}