{"id":"W2883929969","doi":"10.1128/mbio.01143-18","title":"Staphylococcus aureus Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Phagolysosome; Staphylococcus aureus; Microbiology; Biology; Antimicrobial; Macrophage; Immune system; Bacteria; Antimicrobial peptides; Innate immune system; Phagocytosis; Phagosome; Immunology; Biochemistry; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585509,0.0002145387,0.0001401872,0.0001173453,0.00009866963,0.0002243539,0.0001325065,0.0002476464,0.0008297157],"category_scores_gemma":[0.0001002523,0.00009129486,0.0001991601,0.00003674535,0.0001814994,0.0001412255,0.000372876,0.0002782704,0.0003713881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001901261,"about_ca_system_score_gemma":0.0001207334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002259397,"about_ca_topic_score_gemma":0.0001971587,"domain_scores_codex":[0.9998676,0.0000305015,0.0000102827,0.00002531708,0.00003322642,0.000033067],"domain_scores_gemma":[0.9999071,0.00001134459,0.00002847482,0.00001460739,0.00001654999,0.0000218237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002521074,0.000004031946,0.0002536207,0.000005768785,9.41255e-7,0.00002350121,0.000005181086,0.00002637182,0.9992195,0.00004347024,0.00001524147,0.0003770708],"study_design_scores_gemma":[0.00002128215,0.0004839842,0.02616007,0.00001577772,0.00001056609,0.0007194003,0.0001265323,0.004623288,0.9647909,0.0002275456,0.002807476,0.00001322673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993977,0.0008388539,0.003810895,0.0001430751,0.00002541022,0.00001330848,0.00009963057,0.0001057999,0.00098606],"genre_scores_gemma":[0.9969267,0.0001551436,0.00161569,0.00007594683,0.000008809418,0.0000116239,0.0001221914,0.000009834592,0.001074146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008297157,"threshold_uncertainty_score":0.002775729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008515477689745296,"score_gpt":0.2362399919889128,"score_spread":0.2277245142991675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}