{"id":"W2883957385","doi":"10.1242/dev.150888","title":"Gene editing in human development: ethical concerns and practical applications","year":2018,"lang":"en","type":"article","venue":"Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Genome editing; CRISPR; Human genetics; Induced pluripotent stem cell; Germline; Cas9; Computational biology; Gene; Human genome; Genetics; Engineering ethics; Genome; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0330457,0.0003595246,0.0005425872,0.0005564748,0.001322696,0.002848306,0.001203221,0.005389391,0.003858044],"category_scores_gemma":[0.02156116,0.000256588,0.0004416695,0.0004525086,0.01090756,0.001735914,0.00240691,0.005718449,0.001474246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00101596,"about_ca_system_score_gemma":0.00265004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003378151,"about_ca_topic_score_gemma":0.0005291051,"domain_scores_codex":[0.9815833,0.01274948,0.0007625903,0.0008595463,0.003638462,0.0004066764],"domain_scores_gemma":[0.9756867,0.01813443,0.001255362,0.002683594,0.001351741,0.0008881431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002747819,0.0001955469,0.003096676,0.001151081,0.00006052216,0.003947258,0.003051451,0.001311154,0.01318855,0.4486313,0.07686237,0.4482295],"study_design_scores_gemma":[0.00007475057,0.0004657846,0.001495471,0.002084709,0.00005810431,0.01511882,0.001524067,0.001093703,0.007911511,0.2658577,0.7042515,0.00006391085],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02370643,0.2346781,0.1478814,0.4363531,0.00749964,0.0003686305,0.0001256911,0.0003910711,0.1489959],"genre_scores_gemma":[0.4684251,0.1873803,0.1413609,0.1420659,0.007401943,0.00120315,0.00014852,0.0002415357,0.05177268],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0330457,"threshold_uncertainty_score":0.1747644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02111889583151871,"score_gpt":0.3628747471693602,"score_spread":0.3417558513378415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}