{"id":"W2883957385","doi":"10.1242/dev.150888","title":"Gene editing in human development: ethical concerns and practical applications","year":2018,"lang":"en","type":"article","venue":"Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Genome editing; CRISPR; Human genetics; Induced pluripotent stem cell; Germline; Cas9; Computational biology; Gene; Human genome; Genetics; Engineering ethics; Genome; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002087277,0.00009489845,0.00007613171,0.00003413543,0.0001173239,0.00001676541,0.00005064911,0.0001429026,0.00001593176],"category_scores_gemma":[0.00003323718,0.0001006179,0.000009072542,0.00005642177,0.00006331831,0.000001610616,0.0001159021,0.000126376,0.00001216139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000209185,"about_ca_system_score_gemma":0.0001136623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002367712,"about_ca_topic_score_gemma":0.00007682429,"domain_scores_codex":[0.9992628,0.00001350592,0.0001970098,0.0002478332,0.00009109244,0.000187748],"domain_scores_gemma":[0.999745,0.000008448389,0.00002636638,0.0001060464,0.00004388057,0.00007032057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000407487,0.0001868591,0.02775877,0.0001027145,0.0001312227,0.00002184973,0.003997587,0.00003860185,0.8855596,0.001326304,0.003692,0.07714372],"study_design_scores_gemma":[0.0003687665,0.00003601781,0.02368417,0.000013197,0.000002703318,0.00001849801,0.00007369832,0.000022083,0.7154783,0.00002232762,0.2601078,0.0001724753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9339745,0.0001185442,0.06408168,0.0002302423,0.00005731169,0.0001914184,8.571092e-7,0.00001630582,0.001329117],"genre_scores_gemma":[0.9573952,0.00001183606,0.04170075,0.0002370232,0.0003764812,0.00008460202,0.00004911116,0.00001176999,0.0001332537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2564158,"threshold_uncertainty_score":0.4103079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02111889583151871,"score_gpt":0.3628747471693602,"score_spread":0.3417558513378415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}