{"id":"W2883972517","doi":"10.1186/s13041-018-0386-3","title":"Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs","year":2018,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"E-Rare; ALS Society of Canada","keywords":"Amyotrophic lateral sclerosis; microRNA; Biology; Messenger RNA; Neurofilament; Spinal cord; Cell biology; Cytoskeleton; Cytoplasm; Intermediate filament; Neuroscience; Molecular biology; Gene; Cell; Pathology; Genetics; Medicine; Immunology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004200634,0.0001168598,0.0002367959,0.00005973905,0.00007097964,0.00001676026,0.00008707568,0.0001084143,0.0004025189],"category_scores_gemma":[0.0002119838,0.0001019572,0.00005652456,0.000169884,0.0003772989,0.00005106817,0.00008830495,0.000131658,0.00001287049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005777655,"about_ca_system_score_gemma":0.0000371532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002212688,"about_ca_topic_score_gemma":0.00001734553,"domain_scores_codex":[0.9986665,0.0001428945,0.0002613802,0.0002902378,0.000395427,0.0002436205],"domain_scores_gemma":[0.9991734,0.00003886619,0.00006696004,0.0003933963,0.0001712766,0.0001560798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006339386,0.00007836072,0.006606504,0.00004755121,0.00003220805,0.000007240651,0.00024534,2.549487e-7,0.9885612,0.0002049125,0.001759168,0.002393857],"study_design_scores_gemma":[0.001858272,0.0008781162,0.4036559,0.00007218902,0.00002901462,0.000008512215,0.00003506544,0.0005703836,0.5907275,0.00105348,0.0009638281,0.0001476864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938251,0.0001456154,0.0005939169,0.00401906,0.00002086279,0.0004033273,0.000007184329,0.00002980068,0.000955179],"genre_scores_gemma":[0.9985132,0.000004143324,0.0004620629,0.0005300269,0.00005933913,0.000009171061,0.00004289269,0.00002285847,0.0003563123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3978337,"threshold_uncertainty_score":0.44073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02503678447539557,"score_gpt":0.320439315485937,"score_spread":0.2954025310105414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}