{"id":"W2883978276","doi":"10.1038/s41557-018-0084-x","title":"Isolation, synthesis and bioactivity studies of phomactin terpenoids","year":2018,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Division of Chemistry; Japan Society for the Promotion of Science; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins University; Amgen; National Science Foundation","keywords":"Chemistry; Natural product; Isolation (microbiology); Terpenoid; Drug discovery; Total synthesis; Computational biology; Chemical biology; Chemical synthesis; Chemical space; Combinatorial chemistry; Biochemical engineering; In vitro; Biochemistry; Stereochemistry; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265496,0.0001178301,0.0002676522,0.00002274897,0.0000602342,0.000006058263,0.00005018384,0.0002720505,0.0001666615],"category_scores_gemma":[0.001313688,0.00008299734,0.00004530695,0.0001319373,0.000285162,0.00004282742,0.00004559683,0.0002862912,0.000002700905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002789881,"about_ca_system_score_gemma":0.00002992382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005821386,"about_ca_topic_score_gemma":0.000001492786,"domain_scores_codex":[0.9993814,0.00001014353,0.0001400678,0.0002407076,0.0001135579,0.0001140763],"domain_scores_gemma":[0.9992682,0.0001231364,0.00008939907,0.0002056671,0.0002646137,0.00004896128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001437672,0.00004651662,0.001029338,0.0003603878,0.0001092073,0.000002270633,0.0000814161,2.888179e-9,0.9891105,0.00000320921,0.002978982,0.006134447],"study_design_scores_gemma":[0.0001642774,0.0000306468,0.003092161,0.0001510558,0.0001063653,0.00004290808,0.0001454493,0.00000399236,0.9924442,0.00002827906,0.003703676,0.00008699835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917983,0.003836461,0.000001805977,0.002022261,0.0000875962,0.00007908158,0.0000152582,0.00002730801,0.002131862],"genre_scores_gemma":[0.9976997,0.0001794502,0.0007738568,0.0001539493,0.0004877501,5.633815e-7,0.000002919045,0.000009415288,0.0006923415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006047449,"threshold_uncertainty_score":0.3384533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333948184642638,"score_gpt":0.2892233849125944,"score_spread":0.275883903066168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}