{"id":"W2883978276","doi":"10.1038/s41557-018-0084-x","title":"Isolation, synthesis and bioactivity studies of phomactin terpenoids","year":2018,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Division of Chemistry; Japan Society for the Promotion of Science; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins University; Amgen; National Science Foundation","keywords":"Chemistry; Natural product; Isolation (microbiology); Terpenoid; Drug discovery; Total synthesis; Computational biology; Chemical biology; Chemical synthesis; Chemical space; Combinatorial chemistry; Biochemical engineering; In vitro; Biochemistry; Stereochemistry; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165141,0.0002649717,0.0001284993,0.0003755098,0.0001311801,0.0002289459,0.0001189168,0.0001214511,0.0009645586],"category_scores_gemma":[0.0002271373,0.00007476205,0.0002020778,0.000269907,0.000193716,0.0003372768,0.00016374,0.000343389,0.0002748613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001337165,"about_ca_system_score_gemma":0.000144504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004636671,"about_ca_topic_score_gemma":0.0003910098,"domain_scores_codex":[0.9999439,0.00001121281,0.000005842816,0.00001134948,0.00001283322,0.00001485433],"domain_scores_gemma":[0.9999021,0.00003723519,0.00001359648,0.00001200747,0.00001560717,0.00001947058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001407452,0.00003523345,0.0001494421,0.00002961024,0.000003591027,0.00005622204,0.00002329109,0.0001936501,0.9972371,0.00006893351,0.00001048101,0.002051761],"study_design_scores_gemma":[0.000007325737,0.0001649139,0.001386662,0.000002580993,0.000007617212,0.00006047274,0.00001915376,0.0002244297,0.9974788,0.00003620153,0.0006093843,0.000002488571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905128,0.002277517,0.004419521,0.0000768719,0.00001614179,0.00004628288,0.0004358549,0.00001891573,0.002196154],"genre_scores_gemma":[0.9949365,0.001065364,0.00156273,0.00003063273,0.000008826167,0.00001265916,0.0003870364,0.0000109382,0.001985302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009645586,"threshold_uncertainty_score":0.003226757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333948184642638,"score_gpt":0.2892233849125944,"score_spread":0.275883903066168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}