{"id":"W2884001931","doi":"10.1016/j.cell.2018.06.039","title":"Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":748,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of British Columbia; BC Cancer Agency","funders":"V Foundation for Cancer Research; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; Movember Foundation; Howard Hughes Medical Institute; Stand Up To Cancer; U.S. Department of Defense","keywords":"Biology; Chromothripsis; Prostate cancer; Chromoplexy; Carcinogenesis; Transcriptome; Genome instability; Genetics; Androgen receptor; Copy-number variation; Tandem exon duplication; Gene duplication; Cancer research; Structural variation; Exome; Epigenetics; Cancer; Genome; Exome sequencing; Mutation; Gene; DNA damage; DNA; Gene expression; PCA3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002370306,0.0001925562,0.0003235898,0.001137736,0.0003599242,0.0006734314,0.0004217043,0.0005097919,0.004539194],"category_scores_gemma":[0.001682621,0.0001709311,0.0002677111,0.001506685,0.0004087059,0.0004174626,0.0004689899,0.0006114971,0.0002722802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002437494,"about_ca_system_score_gemma":0.0001891025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001684019,"about_ca_topic_score_gemma":0.002578013,"domain_scores_codex":[0.9997332,0.00004898568,0.00001944955,0.00008557222,0.00006982656,0.0000429765],"domain_scores_gemma":[0.9992544,0.0002175622,0.0003055287,0.00008088264,0.00005419035,0.00008738854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001993907,0.0001353861,0.6954957,0.0003105237,0.001158307,0.004034834,0.0007764918,0.00404189,0.186093,0.008890978,0.003576448,0.09349247],"study_design_scores_gemma":[0.00003847441,0.0002022377,0.9656689,0.00003636807,0.0003186344,0.00564423,0.0003676455,0.001998851,0.01034082,0.008691039,0.006661408,0.00003136108],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905687,0.002501649,0.001486769,0.0007953519,0.00003685914,0.000007304519,0.001541589,0.00007037324,0.002991483],"genre_scores_gemma":[0.99828,0.0004055876,0.0003901759,0.0001018962,0.00003550048,0.000002360247,0.0003490771,0.00001789513,0.0004175258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004539194,"threshold_uncertainty_score":0.01518512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02002256703857838,"score_gpt":0.3144128739964921,"score_spread":0.2943903069579138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}