{"id":"W2884038698","doi":"10.1182/blood-2018-02-831503","title":"AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Interreg; State Government of Victoria; National Health and Medical Research Council; Medical Research Council; Fonds De La Recherche Scientifique - FNRS; Fondation Louvain","keywords":"Platelet; AMPK; Hemostasis; Thrombus; Platelet activation; Signal transduction; Chemistry; Cell biology; Dense granule; Lysophosphatidic acid; Pharmacology; Internal medicine; Medicine; Biochemistry; Phosphorylation; Biology; Receptor; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009875932,0.0001157901,0.0001196263,0.00002236583,0.0001008561,0.00004311356,0.0000857732,0.0001033015,0.00006073371],"category_scores_gemma":[0.00002024397,0.0001083053,0.00004092301,0.00005029246,0.00007446145,0.00001067476,0.00005525252,0.00004055438,0.00001919591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000241693,"about_ca_system_score_gemma":0.00001604831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001355398,"about_ca_topic_score_gemma":0.000009392029,"domain_scores_codex":[0.9993408,0.00001993663,0.000142472,0.0002100864,0.00008095127,0.0002057466],"domain_scores_gemma":[0.9996361,0.000003963537,0.0000604506,0.0001701469,0.00007217978,0.00005721047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002826659,0.00008324434,0.001145143,0.00003621812,0.000104812,0.000001057994,0.0002007406,0.000009928865,0.9693285,0.00006278745,0.0009740185,0.02802533],"study_design_scores_gemma":[0.0008500572,0.0001083022,0.0008902819,0.00001240632,0.00004465853,0.00001020324,0.00005007421,0.00008150101,0.9685362,0.0002877964,0.02897413,0.0001543749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9388245,0.06028511,0.0002984847,0.000008828465,0.0001542007,0.0000833503,0.0000142152,0.0000162901,0.000314992],"genre_scores_gemma":[0.9906162,0.007821106,0.0005762885,0.000237802,0.0006019173,0.00000824283,0.00007277728,0.00001672513,0.00004896793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.052464,"threshold_uncertainty_score":0.441656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007384637499569921,"score_gpt":0.2183821100090205,"score_spread":0.2109974725094506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}