{"id":"W2884098295","doi":"10.3389/fonc.2018.00269","title":"Monitoring Immune Checkpoint Regulators as Predictive Biomarkers in Hepatocellular Carcinoma","year":2018,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Immune checkpoint; Immune system; Immunotherapy; Hepatocellular carcinoma; Oncology; Cancer; PD-L1; Internal medicine; Biomarker; Ipilimumab; Clinical trial; Immunology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009159964,0.0002037022,0.00044933,0.002128861,0.0001566921,0.0007025091,0.0002153579,0.000265483,0.0006561843],"category_scores_gemma":[0.001615485,0.00009610095,0.0002655215,0.001893859,0.000130833,0.0002723057,0.0003063348,0.0002616594,0.0002011309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791455,"about_ca_system_score_gemma":0.0002059715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007547627,"about_ca_topic_score_gemma":0.0009817198,"domain_scores_codex":[0.9994805,0.0001551701,0.00007831884,0.00009280711,0.0001341376,0.00005903608],"domain_scores_gemma":[0.9987839,0.0003430722,0.0005525487,0.00007266853,0.0001810569,0.00006673382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005922445,0.00007291885,0.9754504,0.0001170769,0.0001003277,0.0001107104,0.00004528856,0.0003678037,0.006805637,0.00004994414,0.0003156892,0.01597199],"study_design_scores_gemma":[0.00002258134,0.0003976007,0.9787052,0.00004777202,0.0002386379,0.0009474791,0.0001902783,0.003334902,0.01288975,0.0001741578,0.003037988,0.00001361983],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904671,0.005355716,0.0008479519,0.0000970902,0.00001036177,0.00004404427,0.002250791,0.0000464498,0.0008805162],"genre_scores_gemma":[0.9954708,0.0009660779,0.001077789,0.00005804983,0.00002349193,0.00003776392,0.002129943,0.000003488472,0.000232587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002128861,"threshold_uncertainty_score":0.004844248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447370512086838,"score_gpt":0.2836439886567582,"score_spread":0.2691702835358898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}