{"id":"W2884098295","doi":"10.3389/fonc.2018.00269","title":"Monitoring Immune Checkpoint Regulators as Predictive Biomarkers in Hepatocellular Carcinoma","year":2018,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Immune checkpoint; Immune system; Immunotherapy; Hepatocellular carcinoma; Oncology; Cancer; PD-L1; Internal medicine; Biomarker; Ipilimumab; Clinical trial; Immunology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007145581,0.0002318371,0.0006088069,0.0005906912,0.00006341498,0.000009059276,0.0001865728,0.0003783294,0.0001126805],"category_scores_gemma":[0.0001051273,0.000227389,0.0001560978,0.0007043247,0.0005541246,0.00009494075,0.0000687932,0.000331935,0.00001880064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001956111,"about_ca_system_score_gemma":0.0004847787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001259469,"about_ca_topic_score_gemma":0.00004586776,"domain_scores_codex":[0.9979951,0.0001513485,0.0006486305,0.0004607097,0.000216423,0.0005277463],"domain_scores_gemma":[0.9992024,0.0000426722,0.0001629696,0.0003972716,0.00007709039,0.0001175703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0118252,0.0002405109,0.9226295,0.00003570961,0.0002721364,0.0003886489,0.001803096,9.032429e-7,0.02812886,0.000006488288,0.001688563,0.0329804],"study_design_scores_gemma":[0.009582995,0.003956767,0.8479058,0.0003191423,0.00006973135,0.0001416041,0.004076904,0.001582965,0.1089539,0.0003553077,0.02273867,0.0003162558],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820915,0.005621576,0.000239406,0.0008411546,0.004199637,0.000701076,0.000003376722,0.00005121009,0.00625107],"genre_scores_gemma":[0.9950402,0.0004210274,0.003412304,0.0001500265,0.0004376786,0.0000892802,0.000008784259,0.00003712927,0.0004035865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.080825,"threshold_uncertainty_score":0.9272653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447370512086838,"score_gpt":0.2836439886567582,"score_spread":0.2691702835358898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}