{"id":"W2884117835","doi":"10.1093/cid/ciy589","title":"Evolution of Protease Inhibitor Resistance in Human Immunodeficiency Virus Type 1 Infected Patients Failing Protease Inhibitor Monotherapy as Second-line Therapy in Low-income Countries: An Observational Analysis Within the EARNEST Randomized Trial","year":2018,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Instituto de Salud Carlos III; ViiV Healthcare; Gilead Sciences; European and Developing Countries Clinical Trials Partnership; Wellcome Trust; Styrelsen för Internationellt Utvecklingssamarbete; Irish Aid; Pfizer; Medical Research Council; Abbott Laboratories","keywords":"Protease inhibitor (pharmacology); Medicine; Observational study; Randomized controlled trial; Protease; Virology; Human immunodeficiency virus (HIV); Internal medicine; Sida; Immunology; Viral disease; Antiretroviral therapy; Viral load; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01035034,0.0006130896,0.001785374,0.0004317029,0.0004324696,0.001346578,0.0007821487,0.0008141125,0.001669588],"category_scores_gemma":[0.01254301,0.0005202727,0.002308242,0.0007488839,0.0005874937,0.0009354206,0.0007068986,0.00142053,0.0002146144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004868926,"about_ca_system_score_gemma":0.0006073594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007754139,"about_ca_topic_score_gemma":0.0009056299,"domain_scores_codex":[0.9937901,0.004153344,0.0005933344,0.0007247879,0.0004037636,0.0003347912],"domain_scores_gemma":[0.9771467,0.008238669,0.01044813,0.002461411,0.0007051267,0.0009999678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09814765,0.001142188,0.8872173,0.0002677971,0.005426497,0.0001799599,0.0001763978,0.0006710054,0.0004938232,0.0001432347,0.0008479481,0.005286198],"study_design_scores_gemma":[0.02097277,0.02109526,0.9423856,0.0001857222,0.005670426,0.001077402,0.0004406561,0.005773623,0.000642636,0.0004067602,0.001260103,0.00008913021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986609,0.0006165949,0.0001246863,0.00004906773,0.00001168176,0.00004542396,0.0003817814,0.000003561084,0.0001063615],"genre_scores_gemma":[0.9986355,0.0001679159,0.0002149704,0.0000691739,0.00002488136,0.00006788327,0.0007283544,0.000002848819,0.00008848659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01035034,"threshold_uncertainty_score":0.05473852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03196519271251642,"score_gpt":0.3503759325277649,"score_spread":0.3184107398152485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}