{"id":"W2884144545","doi":"10.1016/j.ymben.2018.07.016","title":"Metabolic engineering in the host Yarrowia lipolytica","year":2018,"lang":"en","type":"review","venue":"Metabolic Engineering","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":235,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Office of Naval Research; Natural Sciences and Engineering Research Council of Canada; Welch Foundation; U.S. Department of Energy","keywords":"Yarrowia; Metabolic engineering; Organism; Yeast; Biology; Metabolic pathway; Synthetic biology; Host (biology); Flux (metallurgy); Model organism; Metabolic flux analysis; Industrial microbiology; Saccharomyces cerevisiae; Computational biology; Biochemistry; Metabolism; Chemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004051611,0.000995522,0.001252034,0.001605909,0.0001852305,0.001203763,0.0007089376,0.0007543155,0.001253103],"category_scores_gemma":[0.0003706586,0.0003235969,0.0004264607,0.002428157,0.0003219113,0.001225614,0.0007079699,0.001166777,0.0009863301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004713446,"about_ca_system_score_gemma":0.0006011683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005745616,"about_ca_topic_score_gemma":0.0009227009,"domain_scores_codex":[0.9998379,0.00001695566,0.00002082278,0.00003832388,0.00006477212,0.00002120023],"domain_scores_gemma":[0.999872,0.00004487698,0.00003656223,0.000007408972,0.00002619711,0.00001295423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001204508,0.00009608822,0.0002192605,0.02220699,0.0001219977,0.0003430854,0.00004789002,0.0009274018,0.037032,0.005536294,0.006949339,0.9263992],"study_design_scores_gemma":[0.00002037924,0.0001541349,0.001128237,0.002453092,0.0002183374,0.001318037,0.00005535595,0.0004188731,0.01812932,0.002525924,0.9735401,0.00003809413],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000841184,0.996852,0.0007104967,0.0001338223,0.0001074507,0.000005541808,0.00003263155,0.00001434787,0.001302508],"genre_scores_gemma":[0.003205695,0.9949865,0.0006538227,0.00009449377,0.00004879087,0.00000661596,0.00006528883,0.000004464861,0.0009343284],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001605909,"threshold_uncertainty_score":0.004192054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406582813416732,"score_gpt":0.2529592936478142,"score_spread":0.2388934655136468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}