{"id":"W2884160427","doi":"10.1038/s41598-018-29276-y","title":"A novel triple combination of pharmacological chaperones improves F508del-CFTR correction","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Chemistry; Chaperone (clinical); Computational biology; Pharmacology; Cell biology; Cancer research; Bioinformatics; Biology; Medicine; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515851,0.0004012362,0.0007242148,0.0002628912,0.0001125465,0.0003101758,0.0003074477,0.0003189186,0.001391329],"category_scores_gemma":[0.0001209791,0.0001248389,0.0003457375,0.0001525209,0.0001632927,0.0001939178,0.0002992463,0.000548531,0.0004016372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002328823,"about_ca_system_score_gemma":0.0002457028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004655713,"about_ca_topic_score_gemma":0.001100708,"domain_scores_codex":[0.9998005,0.00001671714,0.00003048285,0.00005439948,0.00006264949,0.000035256],"domain_scores_gemma":[0.9999049,0.000008511056,0.00002383081,0.00001272004,0.00001272299,0.00003725948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106781,0.0000493556,0.0001248785,0.00004838566,0.00001194029,0.00003460389,0.000008284595,0.00006702101,0.9956625,0.00003299147,0.0000514013,0.003797975],"study_design_scores_gemma":[0.00005491206,0.0014918,0.002516111,0.000009100345,0.00004721672,0.0002947156,0.0000143609,0.0005908342,0.9918704,0.0000184079,0.003081223,0.00001107921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928403,0.002441891,0.002532463,0.0001435893,0.00009164021,0.0000786212,0.0003489094,0.0002712241,0.001251391],"genre_scores_gemma":[0.9923142,0.001168554,0.003794672,0.000089735,0.00001988489,0.0000540846,0.0003735352,0.00003382088,0.002151651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391329,"threshold_uncertainty_score":0.004654408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02871886167170366,"score_gpt":0.3410222556924087,"score_spread":0.3123033940207051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}