{"id":"W2884172031","doi":"10.1074/jbc.ra118.004709","title":"Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Fudan University; York University; State of Connecticut Department of Public Health; National Institutes of Health; American Cancer Society","keywords":"Homeostasis; Pancreatic cancer; Glucose homeostasis; Cell biology; Cancer; Biology; Chemistry; Endocrinology; Insulin; Genetics; Insulin resistance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002497381,0.00009166976,0.0001903334,0.00003804481,0.00002466928,0.000006999775,0.0001551967,0.0001949494,0.001031277],"category_scores_gemma":[0.0001628669,0.00006743536,0.0001158029,0.0001502542,0.0001831331,0.000005138797,0.00002748233,0.0001279945,0.000002090537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002691094,"about_ca_system_score_gemma":0.00009185251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001201288,"about_ca_topic_score_gemma":0.000005409366,"domain_scores_codex":[0.9990765,0.00004305382,0.0003959187,0.0001418792,0.0001953753,0.0001472647],"domain_scores_gemma":[0.999286,0.00001510509,0.0001990136,0.0001171544,0.000309293,0.0000734301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004503354,0.00008482511,0.01964339,0.00002658025,0.00003233027,0.000002097973,0.00002594915,0.000008623746,0.9774895,0.000009747986,0.0003539229,0.001872705],"study_design_scores_gemma":[0.000656815,0.0002939961,0.09254424,0.00004493758,0.000007355886,0.00002367437,0.00004617031,0.00004738221,0.9004616,0.0001989387,0.00559593,0.00007899902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975673,0.001051114,0.0002285419,0.0002962595,0.0000367101,0.0000616446,0.00002983212,0.000001720872,0.0007268519],"genre_scores_gemma":[0.9984634,0.0005659835,0.0003329375,0.00007633593,0.0002922877,0.00000448343,0.00002305722,0.000005242933,0.000236256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07702794,"threshold_uncertainty_score":0.9998819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03048063679735673,"score_gpt":0.3125225932754144,"score_spread":0.2820419564780576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}