{"id":"W2884200735","doi":"10.1097/j.pain.0000000000001340","title":"Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy","year":2018,"lang":"en","type":"review","venue":"Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"Astellas Pharma; Allergan; National Institutes of Health; Queen's University; Deutsche Forschungsgemeinschaft; Glenmark Pharmaceuticals; Boston Scientific Corporation; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Teva Pharmaceutical Industries; Celgene; Biogen; Daiichi Sankyo Europe; Advanced Scientific Computing Research; Sanofi; Pfizer; Canadian Institutes of Health Research; Imperial College London; Eli Lilly and Company; AstraZeneca; Novartis Pharma; Physicians' Services Incorporated Foundation","keywords":"Medicine; Placebo; Clinical trial; Neuropathic pain; Randomized controlled trial; Efficacy; Drug; Meta-analysis; Internal medicine; Anesthesia; Pharmacology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3627865,0.002325911,0.005639106,0.006951635,0.0009491963,0.005829345,0.002272981,0.00270709,0.004436747],"category_scores_gemma":[0.6642395,0.001573898,0.02140168,0.01399376,0.00321703,0.006624157,0.004249566,0.004450245,0.0005580268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002357503,"about_ca_system_score_gemma":0.003050319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001772689,"about_ca_topic_score_gemma":0.002510627,"domain_scores_codex":[0.4236177,0.3731743,0.1422972,0.02778833,0.03050348,0.002619014],"domain_scores_gemma":[0.1024111,0.7955139,0.07278597,0.01984469,0.008705238,0.000739096],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"systematic_review","study_design_scores_codex":[0.01031762,0.0002251933,0.3762142,0.09612983,0.3696929,0.0009519007,0.002861107,0.006198811,0.001920129,0.004725628,0.005909622,0.1248531],"study_design_scores_gemma":[0.003551544,0.003575736,0.5164533,0.02897497,0.366318,0.003359757,0.001653772,0.009396611,0.00455916,0.02440919,0.03720417,0.0005438218],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09509535,0.7528365,0.1159339,0.01289118,0.002643462,0.004858856,0.007278373,0.0007201838,0.007742158],"genre_scores_gemma":[0.906848,0.02521567,0.05068459,0.005597637,0.001163144,0.005958443,0.002862089,0.0006887861,0.0009817092],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6372135,"threshold_uncertainty_score":0.7857977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3707763198875562,"score_gpt":0.4855154324866565,"score_spread":0.1147391125991003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}