{"id":"W2884200735","doi":"10.1097/j.pain.0000000000001340","title":"Neuropathic pain clinical trials: factors associated with decreases in estimated drug efficacy","year":2018,"lang":"en","type":"review","venue":"Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"Astellas Pharma; Allergan; National Institutes of Health; Queen's University; Deutsche Forschungsgemeinschaft; Glenmark Pharmaceuticals; Boston Scientific Corporation; National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Teva Pharmaceutical Industries; Celgene; Biogen; Daiichi Sankyo Europe; Advanced Scientific Computing Research; Sanofi; Pfizer; Canadian Institutes of Health Research; Imperial College London; Eli Lilly and Company; AstraZeneca; Novartis Pharma; Physicians' Services Incorporated Foundation","keywords":"Medicine; Placebo; Clinical trial; Neuropathic pain; Randomized controlled trial; Efficacy; Drug; Meta-analysis; Internal medicine; Anesthesia; Pharmacology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.1151207,0.0007835742,0.005313541,0.0003488009,0.00008275123,0.00004361035,0.0002296711,0.0006033799,0.0001346402],"category_scores_gemma":[0.2205274,0.0004640279,0.0009852109,0.0007020042,0.0001241596,0.00003655099,0.00005286998,0.0008696002,0.00007981046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002618773,"about_ca_system_score_gemma":0.0007919263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008454842,"about_ca_topic_score_gemma":0.00006958705,"domain_scores_codex":[0.9301969,0.06594764,0.002024021,0.0008332549,0.0004513942,0.000546804],"domain_scores_gemma":[0.9268179,0.07021904,0.001486647,0.0007961264,0.0001289599,0.0005513424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009267343,0.001721366,0.006950268,0.002246305,0.0009881017,0.0007124708,0.0000474782,1.680529e-7,1.320945e-7,0.000007615199,0.001234493,0.9859989],"study_design_scores_gemma":[0.01506925,0.004429377,0.006383301,0.2915758,0.01752597,0.00004806889,0.0001025875,0.003533046,0.000003973533,0.000147378,0.6589026,0.002278678],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001190734,0.9937814,0.001217982,0.00003483976,0.000252981,0.003080515,0.00007796975,0.0002741513,0.00008946544],"genre_scores_gemma":[0.002009131,0.9946983,0.0003696785,0.000312519,0.000271716,0.0001741115,0.001644846,0.000194066,0.0003255797],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9837202,"threshold_uncertainty_score":0.9997811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3707763198875562,"score_gpt":0.4855154324866565,"score_spread":0.1147391125991003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}