{"id":"W2884226653","doi":"10.1111/jnc.14560","title":"Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's disease mouse models","year":2018,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"Entorhinal cortex; Internal medicine; Endocrinology; Hippocampus; Genetically modified mouse; Cognitive decline; Neurodegeneration; Chemistry; Biology; Transgene; Medicine; Disease; Dementia; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008103855,0.0005905165,0.0002252013,0.0008642211,0.0001770477,0.000324173,0.0001946715,0.0003160296,0.001145457],"category_scores_gemma":[0.00009149034,0.0002825072,0.0003293699,0.0001728723,0.000383504,0.0002845057,0.0002990199,0.0005442286,0.0002532901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003783024,"about_ca_system_score_gemma":0.0002246516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001708857,"about_ca_topic_score_gemma":0.003002481,"domain_scores_codex":[0.9999007,0.000005436497,0.000008531889,0.00003257583,0.00002164661,0.00003100674],"domain_scores_gemma":[0.9997593,0.000006887951,0.0001181757,0.00001171215,0.00002809336,0.00007584131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002371911,0.00002215265,0.0008259039,0.00001647346,0.000008332993,0.00007041992,0.00002675938,0.00002345729,0.9980563,0.00003910535,0.0000252403,0.0006486515],"study_design_scores_gemma":[0.0000374714,0.0006058516,0.09555333,0.00001705501,0.00006422053,0.0007856579,0.000175464,0.0007978263,0.9003955,0.0002145172,0.001337477,0.00001559778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960075,0.0003809445,0.001913441,0.00004834785,0.00001327507,0.00003148567,0.0008916979,0.000115855,0.0005973249],"genre_scores_gemma":[0.9923213,0.0004422406,0.002233282,0.00008024979,0.000004756255,0.00008823261,0.0009577431,0.00005627286,0.003815997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708857,"threshold_uncertainty_score":0.003831923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345482332136346,"score_gpt":0.3016987901283133,"score_spread":0.2882439668069499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}