{"id":"W2884253050","doi":"10.3747/co.25.3936","title":"Overcoming Resistance in a BRAF V600e–Mutant Adenocarcinoma of the Lung","year":2018,"lang":"en","type":"article","venue":"Current Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Dabrafenib; Trametinib; Vemurafenib; Medicine; Adenocarcinoma; V600E; Mutation; Cancer research; Melanoma; Mutant; Oncology; Internal medicine; Cancer; Metastatic melanoma; Biology; MAPK/ERK pathway; Gene; Genetics; Kinase","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259218,0.0004240527,0.0005767319,0.0003627214,0.0004595444,0.0004359615,0.000238731,0.001018956,0.0006618517],"category_scores_gemma":[0.0004212435,0.0001730179,0.0005579551,0.0002017568,0.0001922839,0.0003076339,0.0002716134,0.0008371912,0.00034764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002616821,"about_ca_system_score_gemma":0.0001902963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005272623,"about_ca_topic_score_gemma":0.001304876,"domain_scores_codex":[0.9998677,0.00002350029,0.00001383501,0.00002727762,0.00002087339,0.00004683653],"domain_scores_gemma":[0.9998574,0.00004169981,0.00001787921,0.00001089214,0.00001013179,0.00006194534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.001698556,0.0009191112,0.04315458,0.0003183883,0.0001418095,0.586925,0.0004711449,0.001998971,0.2516477,0.000621087,0.0023157,0.109788],"study_design_scores_gemma":[0.0003317086,0.005938222,0.03538181,0.00003069171,0.0001944056,0.8827458,0.0001838502,0.004334343,0.05684317,0.0004856143,0.01347601,0.00005435452],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892259,0.003583039,0.00154508,0.00151312,0.00009622549,0.0000607384,0.00007352451,0.00007593791,0.003826474],"genre_scores_gemma":[0.9959196,0.001445717,0.001161511,0.0003293398,0.00007472256,0.00001006669,0.00008360209,0.00001076658,0.0009645788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018956,"threshold_uncertainty_score":0.002214134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04052335778572433,"score_gpt":0.3319546082158654,"score_spread":0.2914312504301411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}