{"id":"W2884288683","doi":"10.1093/nar/gky388","title":"Cis-regulatory determinants of MyoD function","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; McGill University; Jewish General Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Canadian HIV Trials Network, Canadian Institutes of Health Research; University of Ottawa; Stem Cell Network; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Ottawa Hospital Research Institute","keywords":"MyoD; Biology; Genetics; Chromatin; Regulatory sequence; DNA binding site; MyoD Protein; Enhancer; Histone; Epigenetics; Transcription factor; Regulation of gene expression; Genome; Computational biology; Gene; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002467247,0.0002571295,0.0003449605,0.0004718099,0.000143696,0.000318397,0.0002651959,0.0002033159,0.002376923],"category_scores_gemma":[0.0003983429,0.0002179817,0.0002433783,0.0002477492,0.0002615776,0.000132606,0.0006120483,0.0003648822,0.0009837825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003090986,"about_ca_system_score_gemma":0.0002066107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000592066,"about_ca_topic_score_gemma":0.001701436,"domain_scores_codex":[0.9995645,0.0000632665,0.00003250871,0.0001931365,0.00009068854,0.00005585252],"domain_scores_gemma":[0.9996954,0.00009577315,0.00007810339,0.00003716853,0.00003418827,0.00005939073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002266013,0.00002526856,0.01203615,0.00008174399,0.00002144239,0.0001403296,0.00004188685,0.0002245632,0.9814858,0.0004980246,0.0001340169,0.005084129],"study_design_scores_gemma":[0.00005391895,0.0001808139,0.4653362,0.00008103524,0.00008905897,0.0009470668,0.0001835574,0.007630608,0.5156104,0.001164187,0.0086749,0.00004829223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853539,0.002269777,0.006978248,0.00009846314,0.00003891651,0.00001709382,0.002926222,0.0001493827,0.002167953],"genre_scores_gemma":[0.9945834,0.000296148,0.002550584,0.00006829714,0.000009589835,0.00001547385,0.001699879,0.00003857222,0.0007379627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002376923,"threshold_uncertainty_score":0.007951558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0358741210824832,"score_gpt":0.3521603677306373,"score_spread":0.3162862466481541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}