{"id":"W2884341400","doi":"10.1016/j.clineuro.2018.07.012","title":"From epidemiology and neurodevelopment to antineoplasticity. Medroxyprogesterone reduces human glial tumor growth in vitro and C6 glioma in rat brain in vivo","year":2018,"lang":"en","type":"article","venue":"Clinical Neurology and Neurosurgery","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Medicine; In vivo; Glioma; In vitro; Cancer research; Brain cancer; Medroxyprogesterone; Human brain; Neuroscience; Oncology; Pharmacology; Internal medicine; Medroxyprogesterone acetate; Cancer; Psychiatry; Genetics; Estrogen; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001181523,0.0002673326,0.0006618911,0.0002172469,0.00007060063,0.00001346465,0.0001199255,0.000425382,0.00000347837],"category_scores_gemma":[0.002902096,0.0002504925,0.00004786499,0.0001886181,0.0006804223,0.00001034918,0.0003387166,0.0005333239,0.000002253497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002828479,"about_ca_system_score_gemma":0.00004102686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000574644,"about_ca_topic_score_gemma":0.00009897693,"domain_scores_codex":[0.9962158,0.001278966,0.0008861796,0.001058948,0.00005774791,0.0005023822],"domain_scores_gemma":[0.997777,0.001649041,0.0001356163,0.0001784397,0.0000221547,0.0002377031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001802706,0.0001305379,0.4478017,0.000008778163,0.000008414593,0.0004683781,0.00003417136,0.000001208692,0.5487761,0.000008782961,0.000405446,0.0005537583],"study_design_scores_gemma":[0.002099623,0.0021857,0.7994871,0.00002929674,0.00001153642,0.0002467576,0.000005992083,0.00009962943,0.1945331,0.0002468954,0.0007455586,0.000308763],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946885,0.0003468425,0.000003779081,0.004049744,0.0006106044,0.0002600461,0.00001249209,0.00001185911,0.0000161251],"genre_scores_gemma":[0.9915115,0.0002993732,0.00006972281,0.007781751,0.000261842,0.00002310612,0.00001594222,0.00002454119,0.00001225321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.354243,"threshold_uncertainty_score":0.9999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194602955558734,"score_gpt":0.3148392518499549,"score_spread":0.2928932222943676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}