{"id":"W2884406388","doi":"10.1242/dev.150433","title":"On the origin of the human germline","year":2018,"lang":"en","type":"review","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Medical Research Council; Cancer Research UK; Astellas Foundation for Research on Metabolic Disorders; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Epiblast; Germline; Induced pluripotent stem cell; Somatic cell; Homeobox protein NANOG; Embryo; Embryonic stem cell; Germ cell; Reprogramming; Cell biology; Germ layer; Genetics; Gene; Gastrulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00052891,0.0004867926,0.0005142091,0.001678886,0.0002824988,0.000623459,0.0005666767,0.0008635992,0.003902552],"category_scores_gemma":[0.0006941143,0.0001843761,0.0002230926,0.001217757,0.0006125972,0.001132431,0.0005574551,0.001267088,0.002152841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005618267,"about_ca_system_score_gemma":0.0009803744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100278,"about_ca_topic_score_gemma":0.001450131,"domain_scores_codex":[0.9998642,0.00002317797,0.0000179047,0.0000301524,0.00005347779,0.00001104624],"domain_scores_gemma":[0.9997203,0.00014397,0.00003488366,0.000008015967,0.00007117026,0.00002163488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004449873,0.00001693195,0.0001584709,0.01203613,0.00003872966,0.0003117165,0.0000977465,0.0002758025,0.001517986,0.014471,0.046963,0.9240679],"study_design_scores_gemma":[0.000003196994,0.00001970288,0.000283185,0.002160433,0.00002225457,0.0005910172,0.00003011801,0.00001814917,0.0002157099,0.001595984,0.995055,0.000005321212],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001020993,0.9965721,0.0001285733,0.0005876487,0.0004633937,0.000003554398,0.00002023867,0.000004916712,0.002117396],"genre_scores_gemma":[0.0007311071,0.9975655,0.0001202821,0.0004236054,0.0002061985,0.000004064021,0.00002531047,0.000001555187,0.0009224215],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003902552,"threshold_uncertainty_score":0.01305532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06685294433068892,"score_gpt":0.3525328457022185,"score_spread":0.2856799013715295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}