{"id":"W2884479282","doi":"10.1530/jme-17-0262","title":"Glucolipotoxic conditions induce β-cell iron import, cytosolic ROS formation and apoptosis","year":2018,"lang":"en","type":"article","venue":"Journal of Molecular Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Reactive oxygen species; Cytosol; Chemistry; Cell biology; Apoptosis; Beta cell; Mitochondrion; Islet; Biochemistry; Insulin; Endocrinology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129152,0.000357141,0.000201086,0.000194981,0.0001280675,0.00023207,0.0001015548,0.000284933,0.0007795295],"category_scores_gemma":[0.00009003477,0.0001015579,0.0002404938,0.00009959944,0.0002472392,0.0001873639,0.0002259739,0.000445277,0.0001067585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167537,"about_ca_system_score_gemma":0.000101044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002146502,"about_ca_topic_score_gemma":0.0002972894,"domain_scores_codex":[0.9999032,0.00001500498,0.00001104667,0.00002520812,0.00002278835,0.00002267084],"domain_scores_gemma":[0.9999266,0.000009644858,0.00003179261,0.000008531776,0.000008938608,0.00001444619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002302622,0.0000308902,0.0003443529,0.00003180588,0.000006155111,0.0001106939,0.00001760471,0.00001770453,0.9983424,0.00005485274,0.00001970799,0.0007935088],"study_design_scores_gemma":[0.00003554427,0.0005023123,0.006617329,0.000008987069,0.00001921437,0.0003876143,0.00004884943,0.0002534934,0.9911962,0.0001098449,0.0008167138,0.000003792481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949452,0.001551742,0.002339206,0.000101038,0.00003426967,0.00002746148,0.0001183389,0.00005204225,0.0008307564],"genre_scores_gemma":[0.9971868,0.0007449494,0.001019121,0.00008832495,0.00001259618,0.00002542817,0.0001482458,0.00000871962,0.0007657436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007795295,"threshold_uncertainty_score":0.002607822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01201617405592987,"score_gpt":0.2665320007772469,"score_spread":0.254515826721317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}