{"id":"W2884517754","doi":"10.1124/dmd.118.082719","title":"Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?","year":2018,"lang":"en","type":"review","venue":"Drug Metabolism and Disposition","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Metabolite; Mechanism (biology); Drug; Liver injury; Cytotoxicity; In vitro toxicology; Biology; Pharmacology; In vitro; Drug development; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003568969,0.001087402,0.002268248,0.0008711859,0.0008223047,0.0001840847,0.0005046466,0.001209119,0.0002590673],"category_scores_gemma":[0.0001598675,0.0009851103,0.0005554418,0.0008767581,0.0002662272,0.0006373318,0.0002534617,0.003223809,0.0004096145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506504,"about_ca_system_score_gemma":0.0003312483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008690538,"about_ca_topic_score_gemma":0.000258329,"domain_scores_codex":[0.9909973,0.004996855,0.001355726,0.001264341,0.000430577,0.0009551837],"domain_scores_gemma":[0.9971724,0.0005709006,0.001004091,0.000605669,0.0001371898,0.0005097091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000528333,0.0005144094,0.00005706622,0.006232946,0.0004705886,0.00008218161,0.00228918,0.000002242289,0.0008543531,0.0003613375,0.004112421,0.9844949],"study_design_scores_gemma":[0.001723873,0.00004758229,0.0002076178,0.002353285,0.004139178,0.00008148007,0.0001183252,0.0004929259,0.006577877,0.0007987397,0.9820621,0.001397031],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06312568,0.9254666,0.00003127918,0.00007785889,0.00418221,0.003064949,0.002224493,0.0002095416,0.001617405],"genre_scores_gemma":[0.08710068,0.9086383,0.00007186108,0.0002915811,0.001722121,0.0007322636,0.0008890542,0.0001154801,0.0004386286],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9830979,"threshold_uncertainty_score":0.9992599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06305219569152005,"score_gpt":0.3899189201407313,"score_spread":0.3268667244492113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}