{"id":"W2884517754","doi":"10.1124/dmd.118.082719","title":"Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?","year":2018,"lang":"en","type":"review","venue":"Drug Metabolism and Disposition","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Metabolite; Mechanism (biology); Drug; Liver injury; Cytotoxicity; In vitro toxicology; Biology; Pharmacology; In vitro; Drug development; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001714911,0.0009775837,0.001944996,0.001361814,0.0001110664,0.001463319,0.0007843172,0.0008904843,0.002574914],"category_scores_gemma":[0.003141817,0.0002804245,0.000870158,0.001262232,0.0003852309,0.001012936,0.0003902293,0.001056854,0.001175623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003095451,"about_ca_system_score_gemma":0.0007851532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008056313,"about_ca_topic_score_gemma":0.001388297,"domain_scores_codex":[0.9993789,0.0001794882,0.00008595273,0.00009955509,0.0002250533,0.0000310582],"domain_scores_gemma":[0.9982888,0.0008426933,0.0003791066,0.00007171133,0.0003842885,0.00003340724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005651923,0.0002822916,0.01880077,0.01551088,0.0009723418,0.00028463,0.00006578676,0.001113246,0.008356833,0.002317697,0.0111775,0.9405528],"study_design_scores_gemma":[0.0002314969,0.002668466,0.05778594,0.01189035,0.006952479,0.008270982,0.0007848876,0.00330011,0.04208273,0.01088795,0.8549237,0.0002210512],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003372888,0.9921622,0.001592041,0.0005092424,0.0002600276,0.00002091092,0.0002972856,0.00002140232,0.001764015],"genre_scores_gemma":[0.02523218,0.9696743,0.001983741,0.0006387067,0.0003875326,0.0000384577,0.0004382115,0.000008869893,0.001597914],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002574914,"threshold_uncertainty_score":0.009069443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06305219569152005,"score_gpt":0.3899189201407313,"score_spread":0.3268667244492113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}