{"id":"W2884522547","doi":"10.1080/14737175.2018.1503536","title":"Clinical and pre-clinical utility of genomics in medulloblastoma","year":2018,"lang":"en","type":"review","venue":"Expert Review of Neurotherapeutics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Garron Family Cancer Centre; Brain Tumour Foundation of Canada; American Brain Tumor Association","keywords":"Medulloblastoma; Sonic hedgehog; Disease; Wnt signaling pathway; Genomics; Medicine; Risk stratification; Oncology; Bioinformatics; Internal medicine; Biology; Cancer research; Genetics; Genome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001955676,0.0004555757,0.003040075,0.00006303631,0.00002233593,0.000004953302,0.0005093765,0.0005498835,0.0000189466],"category_scores_gemma":[0.0007589526,0.000365891,0.0008872489,0.0001696959,0.0009227694,0.000002205193,0.0003437212,0.0003649257,0.000003857499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007242752,"about_ca_system_score_gemma":0.0003924628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003803192,"about_ca_topic_score_gemma":0.000008192208,"domain_scores_codex":[0.9945789,0.001298159,0.002909629,0.0007669116,0.0001929306,0.0002534839],"domain_scores_gemma":[0.9974292,0.0003000953,0.001006857,0.000999984,0.0001641191,0.00009976952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003497688,0.0002756614,0.000523927,0.04984243,0.0003573455,0.000003587632,0.00003379351,1.096172e-8,0.00005897927,0.00000416763,0.001824569,0.9470406],"study_design_scores_gemma":[0.0002338108,0.0006214678,0.0001661491,0.02739843,0.000219607,0.00001691558,0.00000309147,0.000003225726,0.00007444027,0.000005203409,0.9709994,0.0002582991],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000590529,0.9975758,0.00005772486,0.00002992016,0.0004092962,0.001161422,0.00005284113,0.000006376185,0.0001160869],"genre_scores_gemma":[0.00004174327,0.997389,0.001094422,0.0008272365,0.0004510211,0.00005294962,0.00002948098,0.00007208881,0.00004209005],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9691748,"threshold_uncertainty_score":0.9998793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1261948785315,"score_gpt":0.4686245219189017,"score_spread":0.3424296433874018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}