{"id":"W2884524189","doi":"10.1016/j.mib.2018.06.004","title":"Integrating genetic and protein–protein interaction networks maps a functional wiring diagram of a cell","year":2018,"lang":"en","type":"review","venue":"Current Opinion in Microbiology","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; National Science Foundation","keywords":"Biology; Computational biology; Saccharomyces cerevisiae; Protein–protein interaction; Budding yeast; Function (biology); Gene; Phenotype; Model organism; Yeast; Interaction network; Genetics; Systems biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005576597,0.0008778099,0.0008517369,0.001911546,0.0002307985,0.001310777,0.001330072,0.001164317,0.001990811],"category_scores_gemma":[0.0009389315,0.0003200223,0.0003519133,0.002109362,0.001727614,0.002529097,0.0008805165,0.001395514,0.001326604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001131937,"about_ca_system_score_gemma":0.001245733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117114,"about_ca_topic_score_gemma":0.001675333,"domain_scores_codex":[0.9998312,0.00003390906,0.00001861229,0.00004327578,0.00006036861,0.00001262574],"domain_scores_gemma":[0.9996017,0.0002004855,0.00005387223,0.00002691263,0.00009100667,0.00002610951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004543088,0.0000213675,0.000438363,0.007691941,0.00008908407,0.000267564,0.0001092803,0.003296496,0.00954447,0.1471912,0.01719274,0.8141121],"study_design_scores_gemma":[0.00000807982,0.00002853742,0.0009821927,0.001720201,0.0001135229,0.0009369199,0.000105408,0.0015855,0.003067307,0.08784834,0.9035584,0.00004547121],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001524436,0.9531797,0.02988224,0.004685805,0.00106839,0.00002345658,0.000227198,0.000215766,0.009192968],"genre_scores_gemma":[0.009898989,0.9730291,0.01336287,0.0008461311,0.0006115466,0.00003058765,0.0002352882,0.00002052485,0.001964952],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001990811,"threshold_uncertainty_score":0.008212805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03310364993976318,"score_gpt":0.3006734693930014,"score_spread":0.2675698194532382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}