{"id":"W2884681204","doi":"10.1016/j.cell.2018.06.014","title":"Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":315,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Ontario Research Foundation; Movember Foundation; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation; Prostate Cancer Foundation; U.S. Department of Defense","keywords":"Biology; Enhancer; Gene isoform; Transcription factor; Promoter; SNP; Cancer research; Cell cycle; Transcription (linguistics); Gene; Single-nucleotide polymorphism; Genetics; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001844804,0.0002215839,0.000174793,0.0003161188,0.0002868254,0.0005463358,0.0003098433,0.0002733829,0.006305144],"category_scores_gemma":[0.0003518395,0.0003039583,0.0004033925,0.0002397991,0.0002866141,0.0002469019,0.0004383048,0.0008201399,0.0009731102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554413,"about_ca_system_score_gemma":0.0003452971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001464065,"about_ca_topic_score_gemma":0.002619077,"domain_scores_codex":[0.9997059,0.00002850927,0.00001487162,0.0001203476,0.00006910594,0.00006123995],"domain_scores_gemma":[0.9998437,0.00004388745,0.00003975358,0.00002598852,0.00001351186,0.00003311914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002107488,0.00005080679,0.007447748,0.00004981886,0.00003044228,0.0004117193,0.00008990028,0.0002108346,0.9827228,0.002212916,0.0004822225,0.006080051],"study_design_scores_gemma":[0.00008633522,0.0003582138,0.1251867,0.00002925153,0.0001962661,0.002889415,0.000281708,0.008225459,0.8385553,0.002448335,0.02168548,0.00005755775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776196,0.001098857,0.0123082,0.0004814208,0.0001675414,0.00003141703,0.001668614,0.0006646778,0.005959543],"genre_scores_gemma":[0.9948605,0.0002214481,0.0008647655,0.0001049136,0.00001745506,0.00001516691,0.00049569,0.00007429035,0.003345805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006305144,"threshold_uncertainty_score":0.02109283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031096062569456,"score_gpt":0.2856924450106484,"score_spread":0.2753814843849539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}