{"id":"W2884681204","doi":"10.1016/j.cell.2018.06.014","title":"Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":315,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Ontario Research Foundation; Movember Foundation; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation; Prostate Cancer Foundation; U.S. Department of Defense","keywords":"Biology; Enhancer; Gene isoform; Transcription factor; Promoter; SNP; Cancer research; Cell cycle; Transcription (linguistics); Gene; Single-nucleotide polymorphism; Genetics; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002177881,0.0002801576,0.0002032018,0.00005695881,0.0002322704,0.00005717044,0.0003405116,0.0002717465,0.0003125462],"category_scores_gemma":[0.00008747274,0.00026401,0.0001195122,0.0002364245,0.0001557291,0.00001209157,0.0002738629,0.0003496555,0.0002380766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006786642,"about_ca_system_score_gemma":0.0002850922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003600933,"about_ca_topic_score_gemma":0.0002736337,"domain_scores_codex":[0.9979261,0.0001265772,0.0002680387,0.0007292446,0.000304841,0.0006451561],"domain_scores_gemma":[0.9987891,0.00001332488,0.000167579,0.0006205164,0.0002569189,0.0001525865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001460115,0.00007158746,0.00009311662,0.00003931705,0.00007861572,0.000008781036,0.0006289474,0.00003975968,0.9923055,0.000007438903,0.003268557,0.003312387],"study_design_scores_gemma":[0.0008684437,0.000450771,0.0001416542,0.00004010456,0.00003245386,0.000005218205,0.00007615583,0.0003267478,0.8950462,0.0001519277,0.102545,0.0003152897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596434,0.003774046,0.02678251,0.0002646959,0.0007622735,0.000861525,0.0001047678,0.00007174955,0.007735013],"genre_scores_gemma":[0.9892867,0.003398207,0.001523881,0.0003197379,0.0008422045,0.0001593281,0.0001285581,0.00009602747,0.004245383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09927643,"threshold_uncertainty_score":0.9999812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031096062569456,"score_gpt":0.2856924450106484,"score_spread":0.2753814843849539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}