{"id":"W2884762430","doi":"10.29016/180711.1","title":"Retinal Multipotent Stem-Cell Derived “MiEye” Spheroid 3D Culture Model for Preclinical Screening of Non-viral Gene Delivery Systems","year":2018,"lang":"en","type":"article","venue":"Precision Nanomedicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Gene delivery; Retinal; Stem cell; Retina; Cell biology; Biology; 3D cell culture; Multipotent Stem Cell; Viral vector; Neurosphere; Genetic enhancement; Cell culture; Cellular differentiation; Neuroscience; Adult stem cell; Transfection; Gene; Progenitor cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005440031,0.0002394784,0.0003744809,0.00005582347,0.0001090145,0.00001471783,0.0002921385,0.000259624,0.00001424526],"category_scores_gemma":[0.000109076,0.000186373,0.0001441238,0.00008934868,0.0001805368,0.000008524509,0.0001688634,0.00009849675,0.000006947522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001411771,"about_ca_system_score_gemma":0.0001041175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001112151,"about_ca_topic_score_gemma":0.000004647062,"domain_scores_codex":[0.9981429,0.00005435741,0.0006586101,0.0005134813,0.0003175506,0.0003131261],"domain_scores_gemma":[0.9987376,0.00005002982,0.0002803491,0.0003467685,0.0004416965,0.000143521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002182916,0.0001290444,0.001527032,0.0001075894,0.00006127868,0.000001449883,0.0002938045,0.0007519079,0.9746408,0.000001967303,0.005347849,0.0149544],"study_design_scores_gemma":[0.01153887,0.005833291,0.003019827,0.0006279139,0.0002096588,0.00002425091,0.0009264252,0.3348911,0.6210339,0.00004301627,0.02097404,0.0008776988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7217082,0.002247362,0.2743541,0.0000432996,0.000299464,0.0007221273,0.00002688202,0.00001196251,0.0005866238],"genre_scores_gemma":[0.9516366,0.0005834514,0.04309872,0.0001233296,0.0004238659,0.00006095524,0.0002030974,0.00003149087,0.003838452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3536068,"threshold_uncertainty_score":0.760007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256213017366944,"score_gpt":0.28392385021404,"score_spread":0.2613617200403706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}