{"id":"W2884762430","doi":"10.29016/180711.1","title":"Retinal Multipotent Stem-Cell Derived “MiEye” Spheroid 3D Culture Model for Preclinical Screening of Non-viral Gene Delivery Systems","year":2018,"lang":"en","type":"article","venue":"Precision Nanomedicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Gene delivery; Retinal; Stem cell; Retina; Cell biology; Biology; 3D cell culture; Multipotent Stem Cell; Viral vector; Neurosphere; Genetic enhancement; Cell culture; Cellular differentiation; Neuroscience; Adult stem cell; Transfection; Gene; Progenitor cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004742346,0.00045355,0.0003493087,0.0005201753,0.0002950072,0.0004099079,0.0003555676,0.0004387604,0.001127445],"category_scores_gemma":[0.000179547,0.0002093163,0.0004472598,0.0002238693,0.0002337669,0.0002689653,0.0002736296,0.0006433998,0.0004956075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004096395,"about_ca_system_score_gemma":0.0006442481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00179421,"about_ca_topic_score_gemma":0.003733039,"domain_scores_codex":[0.9996457,0.00004217245,0.00003575581,0.00005074051,0.000196327,0.00002936036],"domain_scores_gemma":[0.9997703,0.00006202483,0.00004824095,0.00004350877,0.00003826932,0.00003755164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003780589,0.00004044075,0.0001843518,0.00004817545,0.000005026138,0.00008615865,0.0000313411,0.0004742863,0.9971189,0.0003266603,0.0001137877,0.001533103],"study_design_scores_gemma":[0.000007090803,0.0003397318,0.001256829,0.00001033709,0.00001958984,0.0002298013,0.00002232149,0.003333816,0.9895007,0.0001015902,0.005167183,0.00001091579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7878622,0.004751985,0.1869227,0.0004289881,0.000258215,0.001088356,0.004128376,0.001163504,0.01339571],"genre_scores_gemma":[0.8418503,0.004332538,0.1390883,0.0001653062,0.00002787423,0.001029476,0.003913494,0.0001444626,0.009448293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179421,"threshold_uncertainty_score":0.003771722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256213017366944,"score_gpt":0.28392385021404,"score_spread":0.2613617200403706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}